2,2,2-Trifluoro-1-imidazo[1,2-a]pyridin-3-ylethanone

Base Information

• Chemical Name: 2,2,2-Trifluoro-1-imidazo[1,2-a]pyridin-3-ylethanone
• CAS No.: 503540-28-1
• Molecular Formula: C9H5F3N2O
• Molecular Weight: 214.1440096
• DSSTox Substance ID: DTXSID50408138
• Wikidata: Q82213511
• Mol file: 503540-28-1.mol

Synonyms:503540-28-1;2,2,2-Trifluoro-1-(imidazo[1,2-a]pyridin-3-yl)ethanone;2,2,2-trifluoro-1-{imidazo[1,2-a]pyridin-3-yl}ethan-1-one;2,2,2-Trifluoro-1-(imidazo[1,2-a]pyridin-3-yl)ethan-1-one;2,2,2-trifluoro-1-imidazo[1,2-a]pyridin-3-ylethanone;2,2,2-TRIFLUORO-1-IMIDAZO[1,2-A]PYRIDIN-3-YL-ETHANONE;DTXSID50408138;EN300-1931595;ethanone,2,2,2-trifluoro-1-imidazo[1,2-a]pyridin-3-yl-

Chemical Property of 2,2,2-Trifluoro-1-imidazo[1,2-a]pyridin-3-ylethanone

Chemical Property:

• PSA: 34.37000
• LogP: 2.07930
• XLogP3: 2.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 1
• Exact Mass: 214.03539727
• Heavy Atom Count: 15
• Complexity: 267

Purity/Quality:

99%+ ^*data from raw suppliers

2,2,2-TRIFLUORO-1-IMIDAZO[1,2-A]PYRIDIN-3-YL-ETHANONE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC2=NC=C(N2C=C1)C(=O)C(F)(F)F

Technology Process of 2,2,2-Trifluoro-1-imidazo[1,2-a]pyridin-3-ylethanone

There total 3 articles about 2,2,2-Trifluoro-1-imidazo[1,2-a]pyridin-3-ylethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-aminopyridine (504-29-0) + 3-chloro-4-ethoxy-1,1,1-trifluorobut-3-en-2-one (341527-23-9) → 3-trifluoroacetylimidazo[1,2-a]pyridine (503540-28-1) + (E)-3-chloro-1,1,1-trifluoro-4-(2-pyridinylamino)-3-buten-2-one

Guidance literature:

In dimethyl sulfoxide; at 18 - 23 ℃; for 24h; Further Variations:; Solvents; Product distribution;

DOI:10.1016/S0022-1139(02)00190-2

Reference yield:

2-aminopyridine (504-29-0) + (Z)-3-bromo-4-ethoxy-1,1,1-trifluoro-3-buten-2-one (341527-27-3) → 3-trifluoroacetylimidazo[1,2-a]pyridine (503540-28-1) + (E)-3-bromo-1,1,1-trifluoro-4-(2-pyridinylamino)-3-buten-2-one

Guidance literature:

In chloroform; at 18 - 23 ℃; for 24h; Further Variations:; Solvents; Product distribution;

DOI:10.1016/S0022-1139(02)00190-2

Reference yield:

2-aminopyridine (504-29-0) + (Z)-3-iodo-4-ethoxy-1,1,1-trifluorobut-3-en-2-one (383891-51-8) → 3-trifluoroacetylimidazo[1,2-a]pyridine (503540-28-1) + (E)-3-iodo-1,1,1-trifluoro-4-(2-pyridinylamino)-3-buten-2-one

Guidance literature:

In chloroform; at 18 - 23 ℃; for 24h; Further Variations:; Solvents; Product distribution;

DOI:10.1016/S0022-1139(02)00190-2

upstream raw materials:

2-aminopyridine

3-chloro-4-ethoxy-1,1,1-trifluorobut-3-en-2-one

(Z)-3-bromo-4-ethoxy-1,1,1-trifluoro-3-buten-2-one

(Z)-3-iodo-4-ethoxy-1,1,1-trifluorobut-3-en-2-one

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