Carbamic acid, (3-chloro-2-hydroxypropyl)-, 1,1-dimethylethyl ester (9CI)

Base Information

• Chemical Name: Carbamic acid, (3-chloro-2-hydroxypropyl)-, 1,1-dimethylethyl ester (9CI)
• CAS No.: 570390-94-2
• Molecular Formula: C8H16ClNO3
• Molecular Weight: 209.673
• Mol file: 570390-94-2.mol

Synonyms:Carbamic acid, (3-chloro-2-hydroxypropyl)-, 1,1-dimethylethyl ester (9CI)

Chemical Property of Carbamic acid, (3-chloro-2-hydroxypropyl)-, 1,1-dimethylethyl ester (9CI)

Chemical Property:

• PSA: 58.56000
• LogP: 1.50170

Purity/Quality:

≥95% ^*data from raw suppliers

tert-Butyl 3-chloro-2-hydroxypropylcarbamate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Carbamic acid, (3-chloro-2-hydroxypropyl)-, 1,1-dimethylethyl ester (9CI)

There total 3 articles about Carbamic acid, (3-chloro-2-hydroxypropyl)-, 1,1-dimethylethyl ester (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.71%

di-tert-butyl dicarbonate (24424-99-5) + rac-1-amino-3-chloro-2-propanol hydrochloride (62037-46-1,34839-13-9,54798-66-2) → tert-butyl-3-chloro-2-hydroxypropylcarbamate (570390-94-2)

Guidance literature:

With sodium hydrogencarbonate; In methanol; water; at 20 ℃; for 3h;

Reference yield: 91.0%

C15H20ClNO3 (1125824-66-9) → tert-butyl-3-chloro-2-hydroxypropylcarbamate (570390-94-2)

Guidance literature:

With phosphomolybdic acid; silica gel; In dichloromethane; at 20 ℃; for 4h; chemoselective reaction;

DOI:10.1002/ejoc.200800963

Reference yield: 86.0%

tert-butyldicarbonate (34619-03-9) + rac-1-amino-3-chloro-2-propanol hydrochloride (62037-46-1,34839-13-9,54798-66-2) → tert-butyl-3-chloro-2-hydroxypropylcarbamate (570390-94-2)

Guidance literature:

rac-1-amino-3-chloro-2-propanol hydrochloride; With sodium hydrogencarbonate; In tetrahydrofuran; methanol; water; at 20 ℃; for 0.5h;

tert-butyldicarbonate; In tetrahydrofuran; methanol; water; at 0 ℃; for 2h;

DOI:10.1055/s-0030-1260961

upstream raw materials:

C₁₅H₂₀ClNO₃

tert-butyldicarbonate

rac-1-amino-3-chloro-2-propanol hydrochloride

di-tert-butyl dicarbonate

Downstream raw materials:

(S)-[[3-[4-(2,3-dihydro-1,1-dioxido-4H-1,4-thiazin-4-yl)-3,5-difluorophenyl]-2-oxo-5-oxazolidinyl]methyl]carbamic acid, 1,1-dimethylethyl ester

tert-butyl N-(2-oxiranylmethyl)carbamate