2-Methanesulfonyl-pyrimidine-4-carboxylic acid ethyl ester

Base Information

• Chemical Name: 2-Methanesulfonyl-pyrimidine-4-carboxylic acid ethyl ester
• CAS No.: 503072-46-6
• Molecular Formula: C7H8N2O4S
• Molecular Weight: 216.218
• Hs Code.: 2933599090
• Mol file: 503072-46-6.mol

Synonyms:2-Methanesulfonyl-pyrimidine-4-carboxylic acid ethyl ester;ethyl 2-Methanesulfonyl-pyrimidine-4-carboxylate

Chemical Property of 2-Methanesulfonyl-pyrimidine-4-carboxylic acid ethyl ester

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.511
• Boiling Point: 407.681°C at 760 mmHg
• Flash Point: 200.358°C
• PSA: 94.60000
• Density: 1.338g/cm³
• LogP: 1.13760

Purity/Quality:

85.0-99.9% ^*data from raw suppliers

Ethyl2-(methylsulfonyl)pyrimidine-4-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Methanesulfonyl-pyrimidine-4-carboxylic acid ethyl ester

There total 1 articles about 2-Methanesulfonyl-pyrimidine-4-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-methylsulfanylpyrimidine-4-carboxylic acid (1126-44-9) → methyl 2-(methylsulfonyl)-pyrimidine-4-carboxylate (503072-46-6)

Guidance literature:

With thionyl chloride; In methanol; dichloromethane;

Reference yield: 28.0%

4-((5S,9R)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro-[4.4]nonan-9-yl)benzonitrile (509083-73-2) + methyl 2-(methylsulfonyl)-pyrimidine-4-carboxylate (503072-46-6) → methyl 2-((5S,9R)-9-(4-cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-7-yl)pyrimidine-4-carboxylate (1224465-31-9)

Guidance literature:

In N,N-dimethyl-formamide; at 100 ℃; for 4h; Inert atmosphere;

DOI:10.1021/jm100348u

Reference yield:

methyl 2-(methylsulfonyl)-pyrimidine-4-carboxylate (503072-46-6) + ammonium chloride + phenol (108-95-2,27073-41-2) → 2-phenoxy-pyrimidine-4-carboxylic acid (503072-50-2)

Guidance literature:

With NaH; In tetrahydrofuran;

upstream raw materials:

2-methylsulfanylpyrimidine-4-carboxylic acid

Downstream raw materials:

2-phenoxy-pyrimidine-4-carboxylic acid

methyl 2-((5S,9R)-9-(4-cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-7-yl)pyrimidine-4-carboxylate

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