2-Pyrrolidinecarboxamide,1-(2-methylpropyl)-N-phenyl-,(2S)-(9CI)

Base Information

• Chemical Name: 2-Pyrrolidinecarboxamide,1-(2-methylpropyl)-N-phenyl-,(2S)-(9CI)
• CAS No.: 503314-14-5
• Molecular Formula: C₁₅H₂₂N₂O
• Molecular Weight: 246.352
• Mol file: 503314-14-5.mol

Synonyms:2-Pyrrolidinecarboxamide,1-(2-methylpropyl)-N-phenyl-,(2S)-(9CI)

Chemical Property of 2-Pyrrolidinecarboxamide,1-(2-methylpropyl)-N-phenyl-,(2S)-(9CI)

Chemical Property:

• PSA: 32.34000
• LogP: 2.75640

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Pyrrolidinecarboxamide,1-(2-methylpropyl)-N-phenyl-,(2S)-(9CI)

There total 4 articles about 2-Pyrrolidinecarboxamide,1-(2-methylpropyl)-N-phenyl-,(2S)-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

phenyl isocyanate (103-71-9) + N-(2-methylpropyl)-2-tributylstannyl-pyrrolidine → N-(2-methylpropyl)-pyrrolidine-2-carboxylic acid phenylamide (503314-14-5,503314-15-6)

Guidance literature:

N-(2-methylpropyl)-2-tributylstannyl-pyrrolidine; With n-butyllithium; In diethyl ether; cyclohexane; at 20 ℃; for 1h;

phenyl isocyanate; In diethyl ether; hexane; for 0.5h;

DOI:10.1016/j.tet.2005.01.096

Reference yield:

phenyl isocyanate (103-71-9) + N-(2-methylpropyl)-2-tributylstannyl-pyrrolidine → (R)-N-(2-methylpropyl)-pyrrolidine-2-carboxylic acid phenylamide (503314-14-5,503314-15-6) + (S)-N-(2-methylpropyl)-pyrrolidine-2-carboxylic acid phenylamide (503314-14-5,503314-15-6)

Guidance literature:

N-(2-methylpropyl)-2-tributylstannyl-pyrrolidine; With n-butyllithium; In diethyl ether; hexane; at 22 ℃; for 1h;

phenyl isocyanate; With (-)-sparteine; In diethyl ether; hexane; at -10 ℃; Title compound not separated from byproducts;

DOI:10.1002/1521-3773(20021018)41:20<3887::AID-ANIE3887>3.0.CO;2-J

Reference yield:

phenyl isocyanate (103-71-9) + N-(2-methylpropyl)-2-tributylstannyl-pyrrolidine → (R)-N-(2-methylpropyl)-pyrrolidine-2-carboxylic acid phenylamide (503314-14-5,503314-15-6) + (S)-N-(2-methylpropyl)-pyrrolidine-2-carboxylic acid phenylamide (503314-14-5,503314-15-6)

Guidance literature:

N-(2-methylpropyl)-2-tributylstannyl-pyrrolidine; With n-butyllithium; In diethyl ether; hexane; at 22 ℃; for 1h;

phenyl isocyanate; With (-)-sparteine; In diethyl ether; hexane; at -10 ℃; Title compound not separated from byproducts;

DOI:10.1002/1521-3773(20021018)41:20<3887::AID-ANIE3887>3.0.CO;2-J

upstream raw materials:

phenyl isocyanate