4-Bromo-thiazol-2-ylamine

Base Information

• Chemical Name: 4-Bromo-thiazol-2-ylamine
• CAS No.: 502145-18-8
• Molecular Formula: C3H3BrN2S
• Molecular Weight: 179.04
• Hs Code.: 2934100090
• Mol file: 502145-18-8.mol

Synonyms:2-Amino-4-bromothiazole;2-Thiazolamine, 4-bromo-;4-bromo-1,3-thiazol-2-amine;2-Amino-4-bromothiazole;

Chemical Property of 4-Bromo-thiazol-2-ylamine

Chemical Property:

• Vapor Pressure: 0.00246mmHg at 25°C
• Refractive Index: 1.69
• Boiling Point: 287.6 °C at 760 mmHg
• PKA: 2.17±0.10(Predicted)
• Flash Point: 127.7 °C
• PSA: 67.15000
• Density: 1.976 g/cm³
• LogP: 2.06900
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

Purity/Quality:

97% ^*data from raw suppliers

4-Bromo-2-thiazolamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-Amino-4-bromothiazole is used in the preparation of coumarin derivatives with antimicrobial properties.

Technology Process of 4-Bromo-thiazol-2-ylamine

There total 1 articles about 4-Bromo-thiazol-2-ylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

2-thiazolylamine (96-50-4) → 4-bromo-1,3-thiazol-2-amine (502145-18-8)

Guidance literature:

With N-Bromosuccinimide; In dichloromethane; at 0 - 20 ℃; for 3h; Cooling with ice;

Reference yield: 80.0%

4-bromo-1,3-thiazol-2-amine (502145-18-8) + di-tert-butyl dicarbonate (24424-99-5) → tert-butyl N-(4-bromo-1,3-thiazol-2-yl)carbamate (944804-88-0)

Guidance literature:

With dmap; In dichloromethane; at 25 ℃; for 24h; Inert atmosphere;

DOI:10.1021/acs.joc.8b02655

Reference yield: 71.0%

4-bromo-1,3-thiazol-2-amine (502145-18-8) + 2-(4-((3-cyanopyridin-2-yl)oxy)-3-fluorophenyl)acetic acid → N-(4-bromothiazol-2-yl)-2-(4-((3-cyanopyridin-2-yl)oxy)-3-fluorophenyl)acetamide

Guidance literature:

2-(4-((3-cyanopyridin-2-yl)oxy)-3-fluorophenyl)acetic acid; With thionyl chloride; In 1,2-dichloro-ethane; at 50 ℃; for 1h;

4-bromo-1,3-thiazol-2-amine; With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; for 24h;

upstream raw materials:

2-thiazolylamine

Downstream raw materials:

2-amino-4-(2-furyl)thiazole

C₁₆H₁₈BrN₃O₃S₂

4-(pyridin-3-yl)thiazol-2-amine

tert-butyl N-(4-bromo-1,3-thiazol-2-yl)carbamate

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