7-(3-HYDROXY-PROPOXY)-3H-QUINAZOLIN-4-ONE

Base Information

• Chemical Name: 7-(3-HYDROXY-PROPOXY)-3H-QUINAZOLIN-4-ONE
• CAS No.: 557770-89-5
• Molecular Formula: C11H12N2O3
• Molecular Weight: 220.228
• Hs Code.: 2933990090
• Mol file: 557770-89-5.mol

Synonyms:7-(3-HYDROXY-PROPOXY)-3H-QUINAZOLIN-4-ONE;7-(3-HYDORY-PROPOXY)-3H-QUINAZOLIN-4-ONE

Chemical Property of 7-(3-HYDROXY-PROPOXY)-3H-QUINAZOLIN-4-ONE

Chemical Property:

• Vapor Pressure: 1.77E-10mmHg at 25°C
• Refractive Index: 1.62
• Boiling Point: 491.5°C at 760 mmHg
• Flash Point: 251.1°C
• PSA: 75.21000
• Density: 1.34
• LogP: 0.68430

Purity/Quality:

97% ^*data from raw suppliers

7-(3-Hydroxypropoxy)-4(3H)-quinazolinone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 7-(3-HYDROXY-PROPOXY)-3H-QUINAZOLIN-4-ONE is a substituted quinazolin-4(3H)-one that is used as an intermediate in the preparation of the aurora kinase inhibitor AZD1152 (A808100). 7-(3-Hydroxypropoxy)-4(3H)-quinazolinone is a substituted quinazolin-4(3H)-one that is used as an intermediate in the preparation of the aurora kinase inhibitor AZD1152 (A808100).

Technology Process of 7-(3-HYDROXY-PROPOXY)-3H-QUINAZOLIN-4-ONE

There total 4 articles about 7-(3-HYDROXY-PROPOXY)-3H-QUINAZOLIN-4-ONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

7-fluoro-3H-quinazolin-4-one (16499-57-3) + trimethyleneglycol (504-63-2) → 4-(3-phenylpropylamino)-7-(2-chloroethoxy)quinazoline (557770-89-5)

Guidance literature:

With sodium hydride; In N,N-dimethyl acetamide; at 60 - 110 ℃;

DOI:10.1021/jm061335f

Reference yield: 73.0%

7-fluoro-1H-quinazolin-4-one (16499-57-3) + trimethyleneglycol (504-63-2) → 4-(3-phenylpropylamino)-7-(2-chloroethoxy)quinazoline (557770-89-5)

Guidance literature:

With potassium hydroxide; at 15 - 125 ℃; for 7.83333h;

Reference yield:

7-fluoro-3H-quinazolin-4-one (16499-57-3) → 4-(3-phenylpropylamino)-7-(2-chloroethoxy)quinazoline (557770-89-5)

Guidance literature:

trimethyleneglycol; With sodium hydride; In DMF (N,N-dimethyl-formamide); at 0 - 60 ℃;

7-fluoro-3H-quinazolin-4-one; at 115 ℃; for 3.5h;

With hydrogenchloride; In water; at 0 ℃; pH=5.9;

upstream raw materials:

7-fluoro-1H-quinazolin-4-one

trimethyleneglycol

7-fluoro-3H-quinazolin-4-one

4-fluoroanthranilic acid

Downstream raw materials:

4-chloro-7-(3-chloropropoxy)quinazoline

2-(5-{[7-(3-chloropropoxy)quinazolin-4-yl]amino}-2H-pyrazol-3-yl)-N-(2,3-difluorophenyl)acetamide

2-(5-{[7-(3-chloropropoxy)quinazolin-4-yl]amino}-2H-pyrazol-3-yl)-N-(3-fluorophenyl)acetamide

N-(2,3-difluorophenyl)-2-{3-[(7-{3-[(2R)-2-(2-hydroxymethyl)pyrrolidin-1-yl]propoxy}quinazolin-4-yl)amino]-1H-pyrazol-5-yl}acetamide