Technology Process of Propanedinitrile, (cyclohexylhydroxymethylene)- (9CI)
There total 2 articles about Propanedinitrile, (cyclohexylhydroxymethylene)- (9CI) which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
malononitrile;
With
sodium hydride;
In
tetrahydrofuran;
at 0 ℃;
for 0.5h;
cyclohexanylcarbonyl chloride;
In
tetrahydrofuran;
at 20 ℃;
for 0.5h;
With
hydrogenchloride;
In
tetrahydrofuran; water;
at 20 ℃;
- Guidance literature:
-
malononitrile;
With
sodium hydride;
In
tetrahydrofuran;
at 0 ℃;
for 0.5h;
cyclohexanylcarbonyl chloride;
at 20 ℃;
for 0.5h;
With
hydrogenchloride;
In
water;
- Guidance literature:
-
Multi-step reaction with 9 steps
1: trichlorophosphate / Reflux
2: ammonium hydroxide / 0.5 h / 20 °C
3: hydrogen sulfide; triethylamine / benzene
4: dihydrogen peroxide / methanol / 50 °C
5: sulfuric acid / 0.5 h / 80 °C
6: iodine / N,N-dimethyl acetamide / 1 h / 130 °C
7: trimethylsulphonium iodide; sodium hydride / dimethyl sulfoxide / 18 h / 20 °C
8: water; lithium hydroxide / tetrahydrofuran; methanol / 2 h / 20 °C
9: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 12 h / 20 °C
With
ammonium hydroxide; sulfuric acid; hydrogen sulfide; trimethylsulphonium iodide; water; dihydrogen peroxide; iodine; sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; lithium hydroxide; trichlorophosphate;
In
tetrahydrofuran; methanol; N,N-dimethyl acetamide; dimethyl sulfoxide; N,N-dimethyl-formamide; benzene;
7: Corey-Chaykovsky cyclopropanation;
DOI:10.1016/j.bmcl.2012.03.025
