2-(4-fluorophenyl)-1-methylbenzimidazole

Base Information

• Chemical Name: 2-(4-fluorophenyl)-1-methylbenzimidazole
• CAS No.: 724-59-4
• Molecular Formula: C14H11FN2
• Molecular Weight: 226.253
• Hs Code.: 2916399090
• Mol file: 724-59-4.mol

Synonyms:2-(4-fluorophenyl)-1-methylbenzimidazole

Chemical Property of 2-(4-fluorophenyl)-1-methylbenzimidazole

Chemical Property:

• PSA: 17.82000
• LogP: 3.37940

Purity/Quality:

2-(4-Fluorophenyl)-1-methyl-1H-benzo[d]imidazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-(4-Fluorophenyl)-1-methyl-1H-benzo[d]imidazole has been used as an electrolyte additive used to enhance the performance of dye-sensitized TiO2 solar cells.

Technology Process of 2-(4-fluorophenyl)-1-methylbenzimidazole

There total 12 articles about 2-(4-fluorophenyl)-1-methylbenzimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

para-fluorobenzylamine (140-75-0) + N-methyl-1,2-phenylenediamine (4760-34-3) → 2-(4-fluorophenyl)-1-methyl-1H-benzo[d]imidazole (724-59-4)

Guidance literature:

With palladium 10% on activated carbon; In dodecane; N,N-dimethyl acetamide; at 120 ℃; for 24h; Inert atmosphere;

DOI:10.1039/c3ob40388b

Reference yield: 87.0%

4-fluorobenzaldehyde (459-57-4) + N-methylbenzene-1,2-diamine dihydrochloride (25148-68-9) → 2-(4-fluorophenyl)-1-methyl-1H-benzo[d]imidazole (724-59-4)

Guidance literature:

N-methylbenzene-1,2-diamine dihydrochloride; With triethylamine; In o-xylene; para-xylene; m-xylene; at 120 ℃; for 0.5h; Green chemistry;

4-fluorobenzaldehyde; With potassium carbonate; 1-methyl-3-(n-butyl)imidazolium iodide; In o-xylene; para-xylene; m-xylene; at 120 ℃; for 10h; Green chemistry;

DOI:10.1055/s-0036-1591524

Reference yield: 87.0%

4-fluorobenzaldehyde (459-57-4) + N-methyl-1,2-phenylenediamine (4760-34-3) → 2-(4-fluorophenyl)-1-methyl-1H-benzo[d]imidazole (724-59-4)

Guidance literature:

With palladium 10% on activated carbon; In dodecane; N,N-dimethyl acetamide; at 120 ℃; for 14h; Inert atmosphere;

DOI:10.1039/c3ob40388b

upstream raw materials:

para-fluorobenzylamine

N-methyl-1,2-phenylenediamine

4-fluorobenzaldehyde

4-fluoro-N'-(2-fluorophenyl)-N-methylbenzimidamide

Downstream raw materials:

1-methyl-2-phenylbenzimidazole

Refernces

• 1、 Zhou, Quan,Liu, Shu,Ma, Ming,Cui, He-Zhen,Hong, Xi,Huang, Shuang,Zhang, Jing-Fan,Hou, Xiu-Feng. "N-Heterocyclic Carbene (NHC)-Catalyzed One-Pot Aerobic Oxidative Synthesis of 2-Substituted Benzo[ d ]oxazoles, Benzo[ d ]thiazoles and 1,2-Disubstituted Benzo[ d ]imidazoles". supporting information. p. 1315 - 1322. Retrieved 2018/03/10.
• 2、 Baars, Hannah,Beyer, Astrid,Kohlhepp, Stefanie V.,Bolm, Carsten. "Transition-metal-free synthesis of benzimidazoles mediated by KOH/DMSO". supporting information. p. 536 - 539. Retrieved 2014/04/03.