2,7-Dichloro-1,8-naphthyridine

Base Information

• Chemical Name: 2,7-Dichloro-1,8-naphthyridine
• CAS No.: 55243-02-2
• Molecular Formula: C8H4Cl2N2
• Molecular Weight: 199.039
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID60447654
• Nikkaji Number: J1.801.859D
• Wikidata: Q82266529
• Mol file: 55243-02-2.mol

Synonyms:2,7-dichloro-1,8-naphthyridine;55243-02-2;2,7-DICHLORO-1,8-NAPTHYRIDINE;2,7-Dichloro-1,8-naphthridine;SCHEMBL69979;DTXSID60447654;2,7-dichloro-[1,8]naphthyridine;MFCD08234796;AKOS006286480;MB05733;2,7-DICHLORO[1,8]NAPHTHYRIDINE;AS-31785;CS-0133252;FT-0647178;A854274

Chemical Property of 2,7-Dichloro-1,8-naphthyridine

Chemical Property:

• Vapor Pressure: 0.001mmHg at 25°C
• Melting Point: 258 °C
• Refractive Index: 1.671
• Boiling Point: 312.193 °C at 760 mmHg
• PKA: 0.18±0.30(Predicted)
• Flash Point: 171.691 °C
• PSA: 25.78000
• Density: 1.487 g/cm³
• LogP: 2.93660
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Solubility.: Acetone, DMF, DMSO
• XLogP3: 3.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 197.9751535
• Heavy Atom Count: 12
• Complexity: 149

Purity/Quality:

99% ^*data from raw suppliers

2,7-Dichloro-1,8-naphthyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=NC2=C1C=CC(=N2)Cl)Cl
• Uses: 2,7-Dichloro-1,8-naphthyridine is a compound useful in organic synthesis. 2,7-Dichloro-1,8-naphthyridine (cas# 55243-02-2) is a compound useful in organic synthesis.

Technology Process of 2,7-Dichloro-1,8-naphthyridine

There total 8 articles about 2,7-Dichloro-1,8-naphthyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

2-hydroxy-7-methoxy-1,8-naphthyridine (106582-47-2) → 2,7-dichloro-1,8-naphthyridine (55243-02-2)

Guidance literature:

With trichlorophosphate; at 70 ℃; for 0.166667h; Heating;

DOI:10.1002/jhet.5570230238

Reference yield: 81.0%

2,7-dihydroxy-1,8-naphthyridine (49655-93-8) → 2,7-dichloro-1,8-naphthyridine (55243-02-2)

Guidance literature:

With phosphorus pentachloride; trichlorophosphate; for 2h; Heating;

DOI:10.1021/jo00318a001

Reference yield: 9.6%

→ 2,7-dichloro-1,8-naphthyridine (55243-02-2)

Guidance literature:

upstream raw materials:

2-hydroxy-7-methoxy-1,8-naphthyridine

2,7-dihydroxy-1,8-naphthyridine

2-amino-7-hydroxy-1,8-naphthyridine

2-chloro-7-amino-1,8-naphthyridine

Downstream raw materials:

2-benzyloxy-7-chloro-[1,8]naphthyridine

2,7-diphenyl-[1,8]-naphthyridine

2,7-di(p-tolyl)-1,8-naphthyridine

2,7-bis(2,5-dimethoxyphenyl)-1,8-naphthyridine

Refernces

• 1、 Sarkar, Mithun,Pandey, Pragati,Bera, Jitendra K.. "Chiral 1,8-naphthyridine based ligands: Syntheses and characterization of Di- and tetranuclear copper (I) and silver (I) complexes". . p. 518 - 528. Retrieved 2018/11/24.
• 2、 -. "HETEROCYCLIC COMPOUND AND ORGANIC LIGHT-EMITTING DEVICE". . . Retrieved 2008/12/06.