Cyclopenta[c]pyrrole-1-carboxylic acid, 1,2,3,3a,6,6a-hexahydro-, ethyl ester, (1S,3aR,6aS)- (9CI)

Base Information

Chemical Name:Cyclopenta[c]pyrrole-1-carboxylic acid, 1,2,3,3a,6,6a-hexahydro-, ethyl ester, (1S,3aR,6aS)- (9CI)
CAS No.:667468-14-6
Molecular Formula:C₁₀H₁₅NO₂
Molecular Weight:181.235
Hs Code.:
Mol file:667468-14-6.mol

Synonyms:Cyclopenta[c]pyrrole-1-carboxylic acid, 1,2,3,3a,6,6a-hexahydro-, ethyl ester, (1S,3aR,6aS)- (9CI)

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Chemical Property of Cyclopenta[c]pyrrole-1-carboxylic acid, 1,2,3,3a,6,6a-hexahydro-, ethyl ester, (1S,3aR,6aS)- (9CI)

Chemical Property:

PSA：38.33000
LogP:1.04240

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Cyclopenta[c]pyrrole-1-carboxylic acid, 1,2,3,3a,6,6a-hexahydro-, ethyl ester, (1S,3aR,6aS)- (9CI)

There total 4 articles about Cyclopenta[c]pyrrole-1-carboxylic acid, 1,2,3,3a,6,6a-hexahydro-, ethyl ester, (1S,3aR,6aS)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 402958-21-8,158340-62-6
(1S,3aR,6aS)-4-Oxo-hexahydro-cyclopenta[c]pyrrole-1,2-dicarboxylic acid 2-benzyl ester 1-ethyl ester

: 667468-14-6
(1S,3aR,6aS)-1,2,3,3a,6,6a-Hexahydro-cyclopenta[c]pyrrole-1-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: H₂ / Pd/C / ethyl acetate

2: NaBH₄ / ethanol

3: Tf₂O; i-Pr₂EtN

4: TFA / CH₂Cl₂

With sodium tetrahydroborate; trifluoromethylsulfonic anhydride; hydrogen; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; palladium on activated charcoal; In ethanol; dichloromethane; ethyl acetate;
DOI:10.1016/j.bmcl.2003.09.074

Reference yield:

: 402958-33-2
3,3a,6,6a-tetrahydro-1H-cyclopenta[c]pyrrole-1,2-dicarboxylic acid 2-tert-butyl ester 1-ethyl ester

: 667468-14-6
(1S,3aR,6aS)-1,2,3,3a,6,6a-Hexahydro-cyclopenta[c]pyrrole-1-carboxylic acid ethyl ester

Guidance literature:: With trifluoroacetic acid; In dichloromethane;
DOI:10.1016/j.bmcl.2003.09.074

Reference yield:

: 402958-17-2
(1S,3aR,6aS)-ethyl 2-boc-4-hydroxyoctahydrocyclopenta[c]pyrrole-1-carboxylate

: 667468-14-6
(1S,3aR,6aS)-1,2,3,3a,6,6a-Hexahydro-cyclopenta[c]pyrrole-1-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: Tf₂O; i-Pr₂EtN

2: TFA / CH₂Cl₂

With trifluoromethylsulfonic anhydride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane;
DOI:10.1016/j.bmcl.2003.09.074