4-(4-aminophenoxy)benzonitrile

Base Information

• Chemical Name: 4-(4-aminophenoxy)benzonitrile
• CAS No.: 17076-69-6
• Molecular Formula: C13H10 N2 O
• Molecular Weight: 210.235
• Hs Code.: 2926909090
• Mol file: 17076-69-6.mol

Synonyms:Benzonitrile,p-(p-aminophenoxy)- (8CI); 4-Amino-4'-cyanodiphenyl ether;p-(p-Aminophenoxy)benzonitrile

Chemical Property of 4-(4-aminophenoxy)benzonitrile

Chemical Property:

• Vapor Pressure: 2.17E-06mmHg at 25°C
• Melting Point: 112 °C
• Boiling Point: 393.2°C at 760 mmHg
• PKA: 4.32±0.10(Predicted)
• Flash Point: 191.6°C
• PSA: 59.04000
• Density: 1.23g/cm³
• LogP: 3.51398
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Solubility.: Chloroform (Slightly), Methanol (Slightly)

Purity/Quality:

97% ^*data from raw suppliers

4-(4-Aminophenoxy)benzonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(4-aminophenoxy)benzonitrile

There total 18 articles about 4-(4-aminophenoxy)benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

4-(4-nitrophenoxy)benzonitrile (17076-68-5) → 4-amino-4'-cyanodiphenyl ether (17076-69-6)

Guidance literature:

With hydrazine hydrate; In ethanol; for 3h; Reflux; Inert atmosphere;

DOI:10.1016/j.bmc.2018.03.031

Reference yield: 74.0%

carbon dioxide (124-38-9,18923-20-1) + 4-amino-4'-chlorodiphenyl ether (101-79-1) → 4-amino-4'-cyanodiphenyl ether (17076-69-6)

Guidance literature:

With nickel(II) acetylacetonate; potassium fluoride; phenylsilane; ammonia; zinc; bis(2-diphenylphosphinoethyl)phenylphosphine; In 1-methyl-pyrrolidin-2-one; at 130 ℃; for 20h; under 760.051 Torr; Sealed tube;

DOI:10.1038/s41467-020-17939-2

Reference yield: 73.0%

4-amino-phenol (123-30-8) + 4-nitrobenzonitrile (619-72-7) → 4-amino-4'-cyanodiphenyl ether (17076-69-6)

Guidance literature:

With caesium carbonate; In N,N-dimethyl-formamide; at 100 ℃; for 5h; Inert atmosphere; Schlenk technique; Green chemistry;

DOI:10.3184/174751917X15122516000113

upstream raw materials:

4-(4-nitrophenoxy)benzonitrile

4-Cyanochlorobenzene

4-amino-phenol

4-fluorobenzonitrile

Downstream raw materials:

C₂₉H₂₀N₄O₂

C₄₂H₂₆F₆N₄O₈

1-(4-(4-cyanophenoxy)phenyl)-3-(3,4-dimethoxybenzyl)urea

1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(4-(4-cyanophenoxy)benzyl)urea

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