Technology Process of L-Proline, 4-hydroxy-4-methyl-, (4S)- (9CI)
There total 4 articles about L-Proline, 4-hydroxy-4-methyl-, (4S)- (9CI) which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
borane-ammonia complex; recombinant leucine hydroxylase; oxygen; iron(II); α-ketoglutaric acid disodium salt;
DOI:10.1021/acs.joc.8b00248
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: ascorbic acid; α-ketoglutaric acid disodium salt; iron(II) sulfate; leucine 5-hydroxylase GriE / aq. phosphate buffer / 2 h / 20 °C / pH 7 / Enzymatic reaction
1.2: 4 h
2.1: ascorbic acid; α-ketoglutaric acid disodium salt; iron(II) sulfate; leucine 5-hydroxylase GriE / aq. phosphate buffer / 5 h / 20 °C / pH 7.5 / Enzymatic reaction
3.1: borane-ammonia complex / aq. phosphate buffer / 4 h / pH 7
With
borane-ammonia complex; leucine 5-hydroxylase GriE; iron(II) sulfate; α-ketoglutaric acid disodium salt; ascorbic acid;
In
aq. phosphate buffer;
DOI:10.1021/jacs.7b12918
- Guidance literature:
-
Multi-step reaction with 2 steps
1: ascorbic acid; α-ketoglutaric acid disodium salt; iron(II) sulfate; leucine 5-hydroxylase GriE / aq. phosphate buffer / 5 h / 20 °C / pH 7.5 / Enzymatic reaction
2: borane-ammonia complex / aq. phosphate buffer / 4 h / pH 7
With
borane-ammonia complex; leucine 5-hydroxylase GriE; iron(II) sulfate; α-ketoglutaric acid disodium salt; ascorbic acid;
In
aq. phosphate buffer;
DOI:10.1021/jacs.7b12918
