Benzenemethanamine, alpha-cyclopropyl-4-fluoro-, (alphaS)- (9CI)

Base Information

• Chemical Name: Benzenemethanamine, alpha-cyclopropyl-4-fluoro-, (alphaS)- (9CI)
• CAS No.: 473732-88-6
• Molecular Formula: C10H12FN
• Molecular Weight: 165.2073832
• Hs Code.: 2921499090
• Mol file: 473732-88-6.mol

Synonyms:Benzenemethanamine, alpha-cyclopropyl-4-fluoro-, (alphaS)- (9CI)

Chemical Property of Benzenemethanamine, alpha-cyclopropyl-4-fluoro-, (alphaS)- (9CI)

Chemical Property:

• PSA: 26.02000
• LogP: 2.93580
• Storage Temp.: 2-8°C

Purity/Quality:

99%, ^*data from raw suppliers

(S)-Cyclopropyl(4-fluorophenyl)methanamine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzenemethanamine, alpha-cyclopropyl-4-fluoro-, (alphaS)- (9CI)

There total 8 articles about Benzenemethanamine, alpha-cyclopropyl-4-fluoro-, (alphaS)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.9%

(E)-cyclopropyl(4-fluorophenyl)methanone oxime → α-cyclopropyl-4-fluorobenzylamine (705-14-6,473732-88-6)

Guidance literature:

With palladium on activated charcoal; hydrogen; acetic acid; In ethanol; at 20 ℃; for 12h;

Reference yield: 77.0%

1-cyclopropyl-1-(4-fluoro-phenyl)-methanone O-benzyl oxime (844470-87-7) → (S)-cyclopropyl(4-fluorophenyl)methylamine (473732-88-6)

Guidance literature:

1-cyclopropyl-1-(4-fluoro-phenyl)-methanone O-benzyl oxime; With borane-THF; 1,1-diphenyl-L-valinol; In tetrahydrofuran; at 0 - 20 ℃; for 22.5h;

With hydrogenchloride; In tetrahydrofuran; water; at 0 - 20 ℃; for 6h;

With sodium hydroxide; In tetrahydrofuran; water; at 0 ℃; pH=12;

Reference yield: 67.0%

→ (S)-cyclopropyl(4-fluorophenyl)methylamine (473732-88-6)

Guidance literature:

upstream raw materials:

1-cyclopropyl-1-(4-fluoro-phenyl)-methanone oxime

cyclopropyl(4-fluorophenyl)methanone

1-cyclopropyl-1-(4-fluoro-phenyl)-methanone O-benzyl oxime

α-cyclopropyl-4-fluorobenzylamine

Downstream raw materials:

N-[cyclopropyl(4-fluorophenyl)methyl]-2-(2,4-dichlorophenoxy)propanamide

Refernces

• 1、 -. "AMINE DERIVATIVES AS POTASSIUM CHANNEL BLOCKERS". Page/Page column 101. . Retrieved 2015/09/10.
• 2、 -. "QUINOLINE 4-CARBOXAMIDE DERIVATIVES AND THEIR USE AS NEUROKININ 3 (NK-3) RECEPTOR ANTAGONISTS". Page/Page column 24-25. . Retrieved 2010/02/10.