3-Piperidinecarboxylicacid,2-methyl-,methylester,(2S,3S)-(9CI)

Base Information

• Chemical Name: 3-Piperidinecarboxylicacid,2-methyl-,methylester,(2S,3S)-(9CI)
• CAS No.: 476187-32-3
• Molecular Formula: C8H15NO2
• Molecular Weight: 157.21
• Mol file: 476187-32-3.mol

Synonyms:3-Piperidinecarboxylicacid,2-methyl-,methylester,(2S,3S)-(9CI)

Chemical Property of 3-Piperidinecarboxylicacid,2-methyl-,methylester,(2S,3S)-(9CI)

Chemical Property:

• Boiling Point: 205.9±33.0 °C(Predicted)
• PKA: 9.47±0.10(Predicted)
• PSA: 38.33000
• Density: 0.982±0.06 g/cm3(Predicted)
• LogP: 0.87630

Purity/Quality:

97% ^*data from raw suppliers

Methyl(2S,3S)-2-methyl-piperidine-3-carboxylate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Piperidinecarboxylicacid,2-methyl-,methylester,(2S,3S)-(9CI)

There total 6 articles about 3-Piperidinecarboxylicacid,2-methyl-,methylester,(2S,3S)-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

methyl 2-methylnicotinate (65719-09-7) → methyl (2R*,3R*)-2-methylpiperidine-3-carboxylate (183786-23-4,1864003-05-3,476187-32-3,476187-34-5)

Guidance literature:

With platinum(IV) oxide; palladium 10% on activated carbon; hydrogen; acetic acid; at 20 ℃; for 24h;

DOI:10.1002/chem.202001123

Reference yield: 89.0%

(2S,3R)-1-((S)-2-Hydroxy-1-phenyl-ethyl)-2-methyl-piperidine-3-carboxylic acid methyl ester → (2S,3R)-2-Methyl-piperidine-3-carboxylic acid methyl ester (1864003-05-3,476187-32-3,476187-34-5)

Guidance literature:

With hydrogen; 10percent Pd/C; In methanol; at 20 ℃; for 24h;

DOI:10.1021/jo025955+

Reference yield: 69.0%

(1S)-(2S)-(3S)-1-(2-hydroxy-1-phenyl-ethyl)-2-methyl-piperidine-3-carboxylic acid methyl ester (476187-19-6) → (2S,3S)-2-Methyl-piperidine-3-carboxylic acid methyl ester (1864003-05-3,476187-32-3,476187-34-5)

Guidance literature:

With hydrogen; 10percent Pd/C; In methanol; at 20 ℃; for 24h;

DOI:10.1021/jo025955+

upstream raw materials:

(1S)-(2S)-(3S)-1-(2-hydroxy-1-phenyl-ethyl)-2-methyl-piperidine-3-carboxylic acid methyl ester

(3S)-(8S)-(8aR)-methyl-5-oxo-3-phenyl-hexahydro-oxazolo[3,2-a]pyridine-8-carboxylic acid methyl ester

(3S)-(8R)-(8aR)-methyl-5-oxo-3-phenyl-hexahydro-oxazolo[3,2-a]pyridine-8-carboxylic acid methyl ester

2-methylnicotinic acid

Downstream raw materials:

ethyl cis-2-methylnipecotate

ethyl (2R*,3S*)-2-methylpiperidine-3-carboxylate

(2R,3R)-1-[(tert-butoxy)carbonyl]-2-methylpiperidine-3-carboxylic acid