Chemical Property of Purmorphamine
Chemical Property:
- Appearance/Colour:Light Tan Solid
- Melting Point:210-212 °C
- Boiling Point:790.313 °C at 760 mmHg
- PKA:5.44±0.40(Predicted)
- Flash Point:431.766 °C
- PSA：77.33000
- Density:1.353 g/cm3
- LogP:6.99520
- Storage Temp.:-20°C Freezer
- Solubility.:DMSO: soluble5mg/mL, clear (warmed)
- XLogP3:6.5
- Hydrogen Bond Donor Count:1
- Hydrogen Bond Acceptor Count:7
- Rotatable Bond Count:6
- Exact Mass:520.25867428
- Heavy Atom Count:39
- Complexity:768
- Purity/Quality:
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99%, *data from raw suppliers
Purmorphamine *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
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SDS file from LookChem
Useful:
- Canonical SMILES:C1CCC(CC1)N2C=NC3=C(N=C(N=C32)OC4=CC=CC5=CC=CC=C54)NC6=CC=C(C=C6)N7CCOCC7
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Description
Small molecules that promote osteoblast differentiation might be useful as therapeutic agents for bone diseases such as osteoporosis. Purmorphamine is a 2,6,9-trisubstituted purine that promotes the differentiation of both human and mouse mesenchymal progenitor cells into osteoblasts. The EC50 value for differentiation of C3H10T1/2 cells based on alkaline phosphatase expression is 1 μM. Investigation into purmorphamine’s mechanism of action indicates that it directly binds to and activates the 7-transmembrane Smo receptor of the Hedgehog signaling pathway.
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Uses
An activator of the hedgehog (Hh) signaling pathway. Purmorphamine has been used to study the consequences of upregulation of Hedgehog signalling pathway in Tupfel long fin strain Zebrafish. Activates the Hedgehog pathway by targeting Smoothened
