Homodolicholide

Base Information

Chemical Name:Homodolicholide
CAS No.:86630-40-2
Molecular Formula:C₂₉H₄₈O₆
Molecular Weight:492.697
Hs Code.:

Synonyms:Homodolicholide;28-Homodolicholide;CHEBI:168025;2a,3a,22R,23R-Tetrahydroxy-B-homo-7-oxa-5a-stigmast-24(28)-en-6-one;15-[(E)-3,4-dihydroxy-5-propan-2-ylhept-5-en-2-yl]-4,5-dihydroxy-2,16-dimethyl-9-oxatetracyclo[9.7.0.02,7.012,16]octadecan-8-one

Suppliers and Price of Homodolicholide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of Homodolicholide

Chemical Property:

PSA：107.22000
LogP:3.70020
XLogP3:4.9
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:5
Exact Mass:492.34508925
Heavy Atom Count:35
Complexity:824

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC=C(C(C)C)C(C(C(C)C1CCC2C1(CCC3C2COC(=O)C4C3(CC(C(C4)O)O)C)C)O)O
Isomeric SMILES:C/C=C(\C(C)C)/C(C(C(C)C1CCC2C1(CCC3C2COC(=O)C4C3(CC(C(C4)O)O)C)C)O)O

Technology Process of Homodolicholide

There total 11 articles about Homodolicholide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 87240-58-2
(2R, 3S, 22R, 23R, 24(28)E)-24(28)-ethylidene-22,23-dihydroxy-2,3-isopropylidenedioxy-B-homo-7-oxa-5α-cholestan-6-one

: 86630-40-2
Homodolicholide

Guidance literature:: With acetic acid; In water; at 50 ℃; for 1h;
DOI:10.1016/S0040-4020(01)91129-9

Reference yield:

: 81481-13-2
(22E,24S)-2α,3α-Dihydroxy-5α-stigmast-22-en-6-one 2,3-acetonide

: 86630-40-2
Homodolicholide

Guidance literature:: Multi-step reaction with 3 steps

1: 25.3 percent / m-chloroperbenzoic acid / CH₂Cl₂ / 192 h / Ambient temperature

3: 70.6 percent / aq. acetic acid

With acetic acid; 3-chloro-benzenecarboperoxoic acid; In dichloromethane;

Reference yield:

: 87240-51-5
(2R, 3S, 24S, 22E)-24-ethyl-2,3-isopropylidenedioxy-7-oxa-B-homo-5α-cholest-22-en-6-one

: 86630-40-2
Homodolicholide

Guidance literature:: Multi-step reaction with 5 steps

1: 1) O₃, NaHCO₃; 2) Me₂S / 1) MeOH, -70 deg C, 8 h; 2) -70 deg C

2: 35.9 percent / tetrahydrofuran / 17 h / Ambient temperature

3: 90.5 percent / 80percent MCPBA / CH₂Cl₂ / 1 h / Ambient temperature

4: 55 mg / Al(iPr)3 / toluene / 1 h / Heating

5: 96 percent / AcOH / H₂O / 1 h / 50 °C

With dimethylsulfide; triisopropylaluminium; sodium hydrogencarbonate; ozone; acetic acid; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; dichloromethane; water; toluene;
DOI:10.1016/S0040-4020(01)91129-9