1H-Imidazole-5-methanol,1-propyl-(9CI)

Base Information

• Chemical Name: 1H-Imidazole-5-methanol,1-propyl-(9CI)
• CAS No.: 497855-88-6
• Molecular Formula: C₇H₁₂N₂O
• Molecular Weight: 140.185
• Hs Code.: 2933299090
• Mol file: 497855-88-6.mol

Synonyms:(1-Propyl-1H-imidazol-5-yl)methanol;1H-Imidazole-5-methanol,1-propyl-(9CI);

Chemical Property of 1H-Imidazole-5-methanol,1-propyl-(9CI)

Chemical Property:

• Boiling Point: 327.332 °C at 760 mmHg
• PKA: 14.33±0.10(Predicted)
• Flash Point: 151.765 °C
• PSA: 38.05000
• Density: 1.091 g/cm³
• LogP: 0.78540

Purity/Quality:

97% ^*data from raw suppliers

(1-Propyl-1H-imidazol-5-yl)methanol 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-Imidazole-5-methanol,1-propyl-(9CI)

There total 1 articles about 1H-Imidazole-5-methanol,1-propyl-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

(1-propyl-2-sulfanyl-1H-imidazol-5-yl)methanol (497855-87-5) → (1-propyl-1H-imidazol-5-yl)methanol (497855-88-6)

Guidance literature:

With nitric acid; sodium nitrite; at 20 ℃; for 2h;

DOI:10.1016/j.bmc.2004.10.021

Reference yield:

(1-propyl-1H-imidazol-5-yl)methanol (497855-88-6) → 7-[4-(2-butoxyethoxy)phenyl]-1-isobutyl-N-[4-[[[1-propylimidazol-5-yl]methyl]sulfonyl]phenyl]-2,3-dihydro-1-benzazepine-4-carboxamide

Guidance literature:

Multi-step reaction with 3 steps

1.1: 96 percent / SOCl₂ / Heating

2.1: Et₃N / tetrahydrofuran / 0 - 20 °C

2.2: NaOH / methanol; tetrahydrofuran / 20 °C

2.3: methanol; tetrahydrofuran / 20 °C

3.1: 39 percent / m-chloroperbenzoic acid / CH₂Cl₂ / -78 - -15 °C

With thionyl chloride; triethylamine; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; dichloromethane;

DOI:10.1016/j.bmc.2004.10.021

Reference yield:

(1-propyl-1H-imidazol-5-yl)methanol (497855-88-6) → 7-[4-(2-butoxyethoxy)phenyl]-1-isobutyl-N-[4-[[[1-propylimidazol-5-yl]methyl]sulfanyl]phenyl]-2,3-dihydro-1-benzazepine-4-carboxamide (497853-26-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 96 percent / SOCl₂ / Heating

2.1: Et₃N / tetrahydrofuran / 0 - 20 °C

2.2: NaOH / methanol; tetrahydrofuran / 20 °C

2.3: methanol; tetrahydrofuran / 20 °C

With thionyl chloride; triethylamine; In tetrahydrofuran;

DOI:10.1016/j.bmc.2004.10.021

upstream raw materials:

(1-propyl-2-sulfanyl-1H-imidazol-5-yl)methanol

Downstream raw materials:

7-[4-(2-butoxyethoxy)phenyl]-1-isobutyl-N-[4-[[[1-propylimidazol-5-yl]methyl]sulfanyl]phenyl]-2,3-dihydro-1-benzazepine-4-carboxamide

7-{4-[2-(butoxy)ethoxy]phenyl}-1-propyl-N-({4-[(1-propyl-1H-imidazol-5-yl)methyl]sulfanyl}phenyl)-2,3-dihydro-1H-1-benzazepine-4-carboxamide

(S)-4-{[(1-propyl-1H-imidazol-5-yl)methyl]sulfinyl}phenylamine

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