N-(4-cyanophenyl)-5-fluoro-2-hydroxybenzamide

Base Information

Chemical Name:N-(4-cyanophenyl)-5-fluoro-2-hydroxybenzamide
CAS No.:521272-34-4
Molecular Formula:C14H9FN2O2
Molecular Weight:256.2318632
Hs Code.:
ChEMBL ID:CHEMBL4435520
DSSTox Substance ID:DTXSID90414970
Wikidata:Q82224075
Mol file:521272-34-4.mol

Synonyms:N-(4-cyanophenyl)-5-fluoro-2-hydroxybenzamide;521272-34-4;Benzamide, N-(4-cyanophenyl)-5-fluoro-2-hydroxy-;CHEMBL4435520;DTXSID90414970;AKOS017549580;N-(4-cyanophenyl)-5-fluoro-2-hydroxy-benzamide

Suppliers and Price of N-(4-cyanophenyl)-5-fluoro-2-hydroxybenzamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of N-(4-cyanophenyl)-5-fluoro-2-hydroxybenzamide

Chemical Property:

Melting Point:218-219 °C
Boiling Point:380.9±42.0 °C(Predicted)
PKA:8.05±0.43(Predicted)
Density:1.40±0.1 g/cm3(Predicted)
XLogP3:3.1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:256.06480570
Heavy Atom Count:19
Complexity:371

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC(=CC=C1C#N)NC(=O)C2=C(C=CC(=C2)F)O

Technology Process of N-(4-cyanophenyl)-5-fluoro-2-hydroxybenzamide

There total 4 articles about N-(4-cyanophenyl)-5-fluoro-2-hydroxybenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 873-74-5
4-Aminobenzonitrile

: 2728-74-7
5-fluoro-2-hydroxy-benzoyl chloride

: 521272-34-4
N-(4-cyanophenyl)-5-fluoro-2-hydroxybenzamide

Guidance literature:: In dichloromethane; at 25 ℃; for 12h;
DOI:10.1016/j.bmcl.2019.06.023

Reference yield:

: 345-16-4
5-fluoro-2-hydroxybenzoic acid

: 873-74-5
4-Aminobenzonitrile

: 521272-34-4
N-(4-cyanophenyl)-5-fluoro-2-hydroxybenzamide

Guidance literature:: With phosphorus trichloride; In chlorobenzene; for 3h; Heating;
DOI:10.1002/ardp.200390004

Reference yield:

: 345-16-4
5-fluoro-2-hydroxybenzoic acid

: 521272-34-4
N-(4-cyanophenyl)-5-fluoro-2-hydroxybenzamide

Guidance literature:: Multi-step reaction with 2 steps

1: thionyl chloride; N,N-dimethyl-formamide / dichloromethane / 12 h / 25 °C

2: dichloromethane / 12 h / 25 °C

With thionyl chloride; N,N-dimethyl-formamide; In dichloromethane;
DOI:10.1016/j.bmcl.2019.06.023