(20S)-6-METHOXY-20-(P-TOLUENESULFONOXY-METHYL)-3B,5-CYCLO-5A-PREGNANE

Base Information

Chemical Name:(20S)-6-METHOXY-20-(P-TOLUENESULFONOXY-METHYL)-3B,5-CYCLO-5A-PREGNANE
CAS No.:51231-24-4
Molecular Formula:C30H44O4S
Molecular Weight:500.743
Hs Code.:
Mol file:51231-24-4.mol

Synonyms:(20S)-6-METHOXY-20-(P-TOLUENESULFONOXY-METHYL)-3B,5-CYCLO-5A-PREGNANE

Suppliers and Price of (20S)-6-METHOXY-20-(P-TOLUENESULFONOXY-METHYL)-3B,5-CYCLO-5A-PREGNANE

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Medical Isotopes, Inc.
(3α,5R,6β,20S)-6-Methoxy-3,5-cyclopregnane-30-methanol4-Methylbenzenesulfonate
2.5 mg
$ 725.00

Total 4 raw suppliers

Chemical Property of (20S)-6-METHOXY-20-(P-TOLUENESULFONOXY-METHYL)-3B,5-CYCLO-5A-PREGNANE

Chemical Property:

PSA：60.98000
LogP:7.70100

Purity/Quality:

99% ^*data from raw suppliers

(3α,5R,6β,20S)-6-Methoxy-3,5-cyclopregnane-30-methanol4-Methylbenzenesulfonate ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses (3α,5R,6β,20S)-6-Methoxy-3,5-cyclopregnane-30-methanol 4-Methylbenzenesulfonate is a tosylated derivative that have been utilized in the biosynthetic studies of cholic acids and vitamin D3 derivatives.

Technology Process of (20S)-6-METHOXY-20-(P-TOLUENESULFONOXY-METHYL)-3B,5-CYCLO-5A-PREGNANE

There total 13 articles about (20S)-6-METHOXY-20-(P-TOLUENESULFONOXY-METHYL)-3B,5-CYCLO-5A-PREGNANE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 98-59-9
p-toluenesulfonyl chloride

: (20R)-22-Hydroxy-6β-methoxy-3α,5-cyclo-23,24-dinor-5α-cholane

: 51231-24-4
6β-methoxy-(20S)-methyl-3α,5-cyclo-5α-pregnan-21-ol p-toluenesulfonate

Guidance literature:: With pyridine;

Reference yield: 90.0%

: 51231-23-3
3α,5-cyclo-22-hydroxy-5α-23,24-bisnorcholan-6β-ol 6-methyl ether

: 98-59-9
p-toluenesulfonyl chloride

: 51231-24-4
(20S)-(6β-Methoxy-20-methyl-3α,5-cyclo-5α-pregnan-21-ol)-p-toluolsulfonat

Guidance literature:: With pyridine; dmap; at 0 ℃; for 5h;

Reference yield:

: 53603-94-4
stigmasterol methyl ether

: 51231-24-4
(20S)-(6β-Methoxy-20-methyl-3α,5-cyclo-5α-pregnan-21-ol)-p-toluolsulfonat

Guidance literature:: Multi-step reaction with 2 steps

1.1: ozone / CH₂Cl₂; methanol / 12 h / -78 °C

1.2: 69 percent / NaBH₄ / CH₂Cl₂; methanol; aq. ethanol / 20 °C

2.1: pyridine

With pyridine; ozone; In methanol; dichloromethane; 1.1: Oxidation / 1.2: Reduction / 2.1: Tosylation;
DOI:10.1021/jo991370c