Benzeneacetonitrile, 3-amino-4-hydroxy--alpha--methyl-

Base Information

• Chemical Name: Benzeneacetonitrile, 3-amino-4-hydroxy--alpha--methyl-
• CAS No.: 51234-23-2
• Molecular Formula: C₉H₁₀N₂O
• Molecular Weight: 162.191
• Mol file: 51234-23-2.mol

Synonyms:2-(3-amino-4-hydroxyphenyl) propionitrile;2-(3-amino-4-hydroxy-phenyl)-propionitrile;3-amino-4-hydroxyphenyl-propionitrile;2-(3-amino-4-hydroxyphenyl)propionitrile;2-(3-Amino-4-hydroxyphenyl)-propionitril;3-Amino-4-hydroxyphenyl-α-methylacetonitril;

Chemical Property of Benzeneacetonitrile, 3-amino-4-hydroxy--alpha--methyl-

Chemical Property:

• PSA: 70.04000
• LogP: 2.18268

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzeneacetonitrile, 3-amino-4-hydroxy--alpha--methyl-

There total 5 articles about Benzeneacetonitrile, 3-amino-4-hydroxy--alpha--methyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tin(II)chloride dihydrate + 3-nitro-4-hydroxyphenyl-α-methyl-acetonitrile (51234-22-1,66934-21-2) → 2-(3-amino-4-hydroxyphenyl)-propionitrile (51234-23-2,66934-23-4)

Guidance literature:

With hydrogenchloride; sodium hydroxide; In concentrated hydrochloride acid; ethanol; chloroform; water;

Reference yield:

3-nitro-4-hydroxyphenyl-α-methyl-acetonitrile (51234-22-1,66934-21-2) → 2-(3-amino-4-hydroxyphenyl)-propionitrile (51234-23-2,66934-23-4)

Guidance literature:

With hydrogenchloride; tin(ll) chloride; In ethanol;

DOI:10.1021/jm00235a012

Reference yield:

2-(4-hydroxyphenyl)propanenitrile (21850-61-3) → 2-(3-amino-4-hydroxyphenyl)-propionitrile (51234-23-2,66934-23-4)

Guidance literature:

Multi-step reaction with 2 steps

1: HNO₃ / acetic acid

2: SnCl₂, aq. HCl / ethanol

With hydrogenchloride; nitric acid; tin(ll) chloride; In ethanol; acetic acid;

DOI:10.1021/jm00235a012

upstream raw materials:

3-nitro-4-hydroxyphenyl-α-methyl-acetonitrile

2-(4-hydroxyphenyl)propanenitrile

2-(4-aminophenyl)-propionitrile

Downstream raw materials:

2-[2'-(p-fluorophenyl)-5'-benzoxazolyl]-propionic acid

2-(2-p-chlorophenyl-5-benzoxazolyl)propionitrile

benoxaprofen

2-[2-(4-methoxy-phenyl)-benzooxazol-5-yl]-propionic acid