Benzeneacetic acid, -alpha-,4-bis(1-methylethyl)- (9CI)

Base Information

• Chemical Name: Benzeneacetic acid, -alpha-,4-bis(1-methylethyl)- (9CI)
• CAS No.: 55776-78-8
• Molecular Formula: C14H20O2
• Molecular Weight: 220.31
• Mol file: 55776-78-8.mol

Synonyms:Benzeneacetic acid, -alpha-,4-bis(1-methylethyl)- (9CI)

Chemical Property of Benzeneacetic acid, -alpha-,4-bis(1-methylethyl)- (9CI)

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzeneacetic acid, -alpha-,4-bis(1-methylethyl)- (9CI)

There total 3 articles about Benzeneacetic acid, -alpha-,4-bis(1-methylethyl)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

2-(4-isopropylphenyl)-3-methylbut-2-enoic acid → (S)-2-(4-isopropylphenyl)-3-methylbutanoic acid (55776-78-8)

Guidance literature:

With (+)-1,2-bis((2S,5S)-2,5-diphenylphospholanyl)ethane; hydrogen; cobalt(II) stearate; In tetrahydrofuran; tert-butyl alcohol; at 40 ℃; for 72h; under 60804.1 Torr; enantioselective reaction; Glovebox;

DOI:10.1002/anie.202016705

Reference yield:

(4-isopropylphenyl)acetic acid (4476-28-2) → (S)-2-(4-isopropylphenyl)-3-methylbutanoic acid (55776-78-8)

Guidance literature:

Multi-step reaction with 3 steps

1.1: isopropylmagnesium chloride / tetrahydrofuran / 1 h / 40 °C

1.2: 1.5 h / 25 - 40 °C

2.1: sulfuric acid / dichloromethane / 0.78 h / 20 °C

3.1: cobalt(II) stearate; (+)-1,2-bis((2S,5S)-2,5-diphenylphospholanyl)ethane; hydrogen / tetrahydrofuran; tert-butyl alcohol / 72 h / 40 °C / 60804.1 Torr / Glovebox

With (+)-1,2-bis((2S,5S)-2,5-diphenylphospholanyl)ethane; sulfuric acid; hydrogen; isopropylmagnesium chloride; cobalt(II) stearate; In tetrahydrofuran; dichloromethane; tert-butyl alcohol;

DOI:10.1002/anie.202016705

Reference yield:

C14H20O3 → (S)-2-(4-isopropylphenyl)-3-methylbutanoic acid (55776-78-8)

Guidance literature:

Multi-step reaction with 2 steps

1: sulfuric acid / dichloromethane / 0.78 h / 20 °C

2: cobalt(II) stearate; (+)-1,2-bis((2S,5S)-2,5-diphenylphospholanyl)ethane; hydrogen / tetrahydrofuran; tert-butyl alcohol / 72 h / 40 °C / 60804.1 Torr / Glovebox

With (+)-1,2-bis((2S,5S)-2,5-diphenylphospholanyl)ethane; sulfuric acid; hydrogen; cobalt(II) stearate; In tetrahydrofuran; dichloromethane; tert-butyl alcohol;

DOI:10.1002/anie.202016705

upstream raw materials:

(4-isopropylphenyl)acetic acid