1-Azido-3-chloro-2-propanol

Base Information

• Chemical Name: 1-Azido-3-chloro-2-propanol
• CAS No.: 51275-91-3
• Molecular Formula: C3H6ClN3O
• Molecular Weight: 135.553
• Hs Code.: 2929909090
• DSSTox Substance ID: DTXSID50450339
• Nikkaji Number: J1.086.905F
• Mol file: 51275-91-3.mol

Synonyms:3-Chloro-1-azidoisopropanol;

Chemical Property of 1-Azido-3-chloro-2-propanol

Chemical Property:

• Boiling Point: 44-48 °C(Press: 0.5 Torr)
• PSA: 69.98000
• Density: 1.291 g/cm3(Temp: 25 °C)
• LogP: 0.34916
• Storage Temp.: Refrigerator
• Solubility.: Chloroform
• XLogP3: 1.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 135.0199395
• Heavy Atom Count: 8
• Complexity: 101

Purity/Quality:

98%Min ^*data from raw suppliers

1-Azido-3-chloro-2-propanol,TechnicalGrade ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C(C(CCl)O)N=[N+]=[N-]

Technology Process of 1-Azido-3-chloro-2-propanol

There total 8 articles about 1-Azido-3-chloro-2-propanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

epichlorohydrin (106-89-8,24969-06-0,13403-37-7) → 1-azido-3-chloro-propan-2-ol (51275-91-3)

Guidance literature:

With triethylammonium azide; In diethyl ether; at 25 ℃; for 4h;

Reference yield: 93.0%

(2-azido-1-chloromethylethyloxy)tert-butyldimethylsilane → 1-azido-3-chloro-propan-2-ol (51275-91-3)

Guidance literature:

With phosphomolybdic acid hydrate; silica gel; In tetrahydrofuran; at 20 ℃; for 0.25h;

DOI:10.1021/jo0502697

Reference yield: 91.0%

epichlorohydrin (106-89-8,24969-06-0,13403-37-7) → 1-azido-3-chloro-propan-2-ol (51275-91-3) + C3H6ClN3O

Guidance literature:

With sodium azide; glycerol-tri(3-methylimidazolium) trimesylate; In water; at 60 ℃; for 1.66667h;

DOI:10.1016/j.molliq.2015.04.058

upstream raw materials:

1,3-Dichloro-2-propanol

epichlorohydrin

1-azido-2-trimethylsilyloxy-3-chloro propane

Downstream raw materials:

2-hydroxy-3-chloropropylamine

Refernces

• 1、 Ingham et al.. "-". . p. 373. Retrieved 1956.
• 2、 Khoee, Sepideh,Karimi, Mohammad Reza. "Dual-drug loaded Janus graphene oxide-based thermoresponsive nanoparticles for targeted therapy". . p. 80 - 98. Retrieved 2018.
• 3、 Escandón-Mancilla, Flor M.,Bautista-Renedo, Joanatan M.,Corona-Becerril, David,Reyes, Horacio,Unnamatla, M. V. Basavanag,García-Eleno, Marco Antonio,González-Rivas, Nelly,Cuevas-Ya?ez, Erick. "A Simple, General Method for the Synthesis of 1-Chloro-3-(1,2,3-triazol-1-yl)-propan-2-ol Derivatives and Computational Analysis Thereof". . p. 518 - 527. Retrieved 2021/09/14.
• 4、 Eymann, John,Dhenain, Anne,Joucla, Lionel,Jacob, Guy,Lac?te, Emmanuel,Darwich, Chaza. "Solvent-free Synthesis and Properties of Functionalized Hydrazines and Bishydrazines as Energetic Ingredients for Propulsion Applications". supporting information. p. 4347 - 4357. Retrieved 2020/11/30.