3-Bromo-7-methylimidazo[1,2-A]pyridine

Base Information

• Chemical Name: 3-Bromo-7-methylimidazo[1,2-A]pyridine
• CAS No.: 56051-32-2
• Molecular Formula: C8H7BrN2
• Molecular Weight: 211.06
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID70587530
• Wikidata: Q72447185
• Mol file: 56051-32-2.mol

Synonyms:3-BROMO-7-METHYLIMIDAZO[1,2-A]PYRIDINE;56051-32-2;3-Bromo-7-methyl-imidazo[1,2-a]pyridine;MFCD08056208;SCHEMBL790620;DTXSID70587530;VLFVKNYEPJOABL-UHFFFAOYSA-N;AKOS005256925;AB43022;MCULE-1456638046;TS-03005;3-bromo-7-methylimidazo[1,2-alpha]pyridine;AM20061329;CS-0038367;A25308;W12680;EN300-1197266;J-512086;3-Bromo-7-methylimidazo[1,2-a]pyridine, AldrichCPR

Chemical Property of 3-Bromo-7-methylimidazo[1,2-A]pyridine

Chemical Property:

• Refractive Index: 1.663
• PKA: 4.48±0.50(Predicted)
• PSA: 17.30000
• Density: 1.6g/cm³
• LogP: 2.40520
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• XLogP3: 3.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 209.97926
• Heavy Atom Count: 11
• Complexity: 151

Purity/Quality:

97% ^*data from raw suppliers

3-Bromo-7-methylimidazo[1,2-a]pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T
• Hazard Codes: T,Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC2=NC=C(N2C=C1)Br

Technology Process of 3-Bromo-7-methylimidazo[1,2-A]pyridine

There total 1 articles about 3-Bromo-7-methylimidazo[1,2-A]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

7-Methyl-imidazo[1,2-a]pyridine (874-39-5) → 3-bromo-7-methyl-imidazo[1,2-a]pyridine (56051-32-2)

Guidance literature:

With sodium bromite; acetic acid; In N,N-dimethyl-formamide; at 60 ℃; for 10h; regioselective reaction;

DOI:10.1039/c7ra12100h

Reference yield: 93.0%

3-methoxyphenylboronic acid (10365-98-7,1107579-37-2) + 3-bromo-7-methyl-imidazo[1,2-a]pyridine (56051-32-2) → 3-(3-methoxyphenyl)-7-methylimidazo[1,2-a]pyridine (342613-56-3)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In 1,2-dimethoxyethane; for 17h; Heating;

DOI:10.1021/jm051065l

Reference yield:

3-bromo-7-methyl-imidazo[1,2-a]pyridine (56051-32-2) → 3-(7-methylimidazo[1,2-a]pyridin-3-yl)phenol (342613-57-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 93 percent / aq. Na₂CO₃; Pd(PPh₃)4 / 1,2-dimethoxy-ethane / 17 h / Heating

2: 95 percent / HBr; AcOH / 18 h / Heating

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; hydrogen bromide; sodium carbonate; acetic acid; In 1,2-dimethoxyethane;

DOI:10.1021/jm051065l

upstream raw materials:

7-Methyl-imidazo[1,2-a]pyridine

Downstream raw materials:

3-(3-methoxyphenyl)-7-methylimidazo[1,2-a]pyridine

3-(7-methylimidazo[1,2-a]pyridin-3-yl)phenol

trifluoromethanesulfonic acid 3-(7-methylimidazo[1,2-a]pyridin-3-yl)phenyl ester