6-METHYLOXINDOLE

Base Information

• Chemical Name: 6-METHYLOXINDOLE
• CAS No.: 56341-38-9
• Molecular Formula: C9H9NO
• Molecular Weight: 147.177
• Hs Code.: 2933790090
• Mol file: 56341-38-9.mol

Synonyms:6-METHYLOXINDOLE;6-methylindolin-2-one

Chemical Property of 6-METHYLOXINDOLE

Chemical Property:

• Vapor Pressure: 0.000451mmHg at 25°C
• Melting Point: 179-180 °C(Solv: water (7732-18-5); ethanol (64-17-5))
• Refractive Index: 1.575
• Boiling Point: 315°C at 760 mmHg
• PKA: 14.31±0.20(Predicted)
• Flash Point: 181.1°C
• PSA: 29.10000
• Density: 1.155g/cm³
• LogP: 1.62760
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

6-Methylindolin-2-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-METHYLOXINDOLE

There total 14 articles about 6-METHYLOXINDOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

1-METHOXY-6-METHYLINDOLIN-2-ONE (121989-34-2) → 6-methyl-2-indolinone (56341-38-9)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol;

DOI:10.1021/jo00275a027

Reference yield: 84.0%

ethyl 2-(4-methyl-2-nitrophenyl)acetate → 6-methyl-2-indolinone (56341-38-9)

Guidance literature:

With acetic acid; zinc; In ethanol; at 70 ℃; for 4h; Inert atmosphere;

DOI:10.1039/c6ob01979j

Reference yield: 83.0%

3-Methylacetanilide (537-92-8) + ethyl iodoacetae (623-48-3) → 6-methyl-2-indolinone (56341-38-9)

Guidance literature:

With silver(I) acetate; palladium diacetate; trifluoroacetic acid; at 120 ℃; for 24h; regioselective reaction; Sealed tube; Inert atmosphere; Schlenk technique;

DOI:10.1055/s-0035-1561856

upstream raw materials:

(4-methyl-2-nitro-phenyl)-acetic acid

1-METHOXY-6-METHYLINDOLIN-2-ONE

N-Methoxy-2-p-tolyl-acetamide

N-chloro-N-methoxy-2-(4-methylphenyl)acetamide

Downstream raw materials:

6-methyl-1-(3-nitrophenyl)indolin-2-one

6-methyl-2-oxo-indoline-3-carbaldehyde

Refernces

• 1、 -. "AMP-ACTIVATED PROTEIN KINASE INHIBITORS AND METHODS OF MAKING AND USING THE SAME". Page/Page column 78-79. . Retrieved 2021/01/23.
• 2、 -. "Method for preparing indole and derivatives thereof". Paragraph 0085-0088; 0090. . Retrieved 2017/08/24.