5-Benzoxazolecarboxylicacid,2-amino-,ethylester(9CI)

Base Information

• Chemical Name: 5-Benzoxazolecarboxylicacid,2-amino-,ethylester(9CI)
• CAS No.: 56350-62-0
• Molecular Formula: C10H10N2O3
• Molecular Weight: 206.2
• Mol file: 56350-62-0.mol

Synonyms:5-Benzoxazolecarboxylicacid,2-amino-,ethylester(9CI)

Chemical Property of 5-Benzoxazolecarboxylicacid,2-amino-,ethylester(9CI)

Chemical Property:

• PSA: 79.08000
• LogP: 1.51680

Purity/Quality:

Ethyl2-aminobenzo[d]oxazole-5-carboxylate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-Benzoxazolecarboxylicacid,2-amino-,ethylester(9CI)

There total 4 articles about 5-Benzoxazolecarboxylicacid,2-amino-,ethylester(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C13H11N2O3(1+) → 2-amino-5-ethoxycarbonylbenzoxazole (56350-62-0)

Guidance literature:

With piperidine; In acetonitrile; at 70 ℃; for 3h; Inert atmosphere;

DOI:10.1002/chem.201406398

Reference yield:

4-ethoxycarbonyl(2-pyrimidinyloxy)benzene → 2-amino-5-ethoxycarbonylbenzoxazole (56350-62-0)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate; trifluorormethanesulfonic acid; lithium perchlorate / acetonitrile / 20 °C / Inert atmosphere; Electrolysis

2: piperidine / acetonitrile / 3 h / 70 °C / Inert atmosphere

With piperidine; trifluorormethanesulfonic acid; lithium perchlorate; potassium carbonate; In acetonitrile;

DOI:10.1002/chem.201406398

Reference yield:

Ethyl 4-hydroxybenzoate (120-47-8) → 2-amino-5-ethoxycarbonylbenzoxazole (56350-62-0)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate; copper(l) iodide; iron(III)-acetylacetonate / N,N-dimethyl-formamide / 24 h / 135 °C / Inert atmosphere

2: potassium carbonate; trifluorormethanesulfonic acid; lithium perchlorate / acetonitrile / 20 °C / Inert atmosphere; Electrolysis

3: piperidine / acetonitrile / 3 h / 70 °C / Inert atmosphere

With piperidine; copper(l) iodide; iron(III)-acetylacetonate; trifluorormethanesulfonic acid; lithium perchlorate; potassium carbonate; In N,N-dimethyl-formamide; acetonitrile;

DOI:10.1002/chem.201406398

upstream raw materials:

bromocyane

ethyl 4-hydroxy-3-nitrobenzoate

Ethyl 4-hydroxybenzoate