(2-Fluorobenzyl)hydrazine

Base Information

• Chemical Name: (2-Fluorobenzyl)hydrazine
• CAS No.: 51859-98-4
• Molecular Formula: C7H9FN2
• Molecular Weight: 140.16
• Hs Code.: 2928000090
• European Community (EC) Number: 812-035-6
• Nikkaji Number: J1.500.690K
• Mol file: 51859-98-4.mol

Synonyms:(2-Fluorobenzyl)hydrazine;51859-98-4;2-Fluorobenzylhydrazine;(2-fluorophenyl)methylhydrazine;[(2-fluorophenyl)methyl]hydrazine;1-(2-FLUOROBENZYL)HYDRAZINE;Hydrazine, [(2-fluorophenyl)methyl]-;o-fluorobenzylhydrazine;2-fluorobenzyl-hydrazine;SCHEMBL597128;OOMBRKGIWITBLL-UHFFFAOYSA-N;MFCD07785903;AKOS000155147;GS-6675;PB23531;AM20050453;BB 0262155;CS-0053072;FT-0684633;EN300-241669;A828815;F2169-0403

Chemical Property of (2-Fluorobenzyl)hydrazine

Chemical Property:

• Vapor Pressure: 0.00895mmHg at 25°C
• Refractive Index: ">
• Boiling Point: 265.8 °C at 760 mmHg
• PKA: 6.74±0.10(Predicted)
• Flash Point: 114.6 °C
• PSA: 38.05000
• Density: 1.144g/cm³
• LogP: 1.88020
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• XLogP3: 0.8
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 140.07497646
• Heavy Atom Count: 10
• Complexity: 97.6

Purity/Quality:

≥99% ^*data from raw suppliers

2-Fluorobenzylhydrazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C(=C1)CNN)F
• Uses: 2-Fluorobenzylhydrazine has been used as a reactant for the synthesis of acylamino substituted benzylbenzohydrazide derivatives.

Technology Process of (2-Fluorobenzyl)hydrazine

There total 3 articles about (2-Fluorobenzyl)hydrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

tert-butyl 2-(2-fluorobenzyl)hydrazinecarboxylate → (2-fluorobenzyl)hydrazine (51859-98-4)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; dichloromethane; at 20 ℃; for 1.5h;

Reference yield: 47.0%

o-fluorobenzyl bromide (446-48-0) → (2-fluorobenzyl)hydrazine (51859-98-4)

Guidance literature:

With hydrazine hydrate; In ethanol; Heating; a) reflux, 5 h, b) RT, 18 h;

DOI:10.1021/jm00019a019

Reference yield:

2-fluorobenzyl chloride (345-35-7) → (2-fluorobenzyl)hydrazine (51859-98-4)

Guidance literature:

With hydrazine hydrate; In ethanol; for 1.5h; Reflux;

DOI:10.1021/jf303376t

upstream raw materials:

o-fluorobenzyl bromide

2-fluorobenzyl chloride

Downstream raw materials:

5-amino-1-(2-fluorobenzyl)pyrazole-4-carbonitrile

5-Amino-4-ethoxycarbonyl-1-(2-fluorobenzyl)pyrazole

4-amino-5-chloro-3-<1-(2-fluorobenzyl)hydrazino>pyridazine

ethyl 5-amino-1-(2-fluorobenzyl)-1H-pyrazole-3-carboxylate