(1S,4S)-2,5-Diazabicyclo[2.2.1]heptane dihydrochloride

Base Information

Chemical Name:(1S,4S)-2,5-Diazabicyclo[2.2.1]heptane dihydrochloride
CAS No.:5260-20-8
Molecular Formula:C₅H₁₀N₂*2ClH
Molecular Weight:171.07
Hs Code.:
European Community (EC) Number:820-182-2
Mol file:5260-20-8.mol

Synonyms:5260-20-8;(1S,4S)-2,5-Diazabicyclo[2.2.1]heptane dihydrochloride;2,5-Diazabicyclo[2.2.1]heptane, dihydrochloride;(1S,4S)-2,5-diazabicyclo[2.2.1]heptane;dihydrochloride;C5H12Cl2N2;(1S, 4S)-2,5-Diaza-bicyclo[2.2.1]heptane dihydrochloride;MFCD28098133;SCHEMBL9750316;AKOS027322228;CS-0183839;EN300-343647;F18872;(1S,4S)-2,5-Diazabicyclo[2.2.1]heptanedihydrochloride;(1S, 4S)-2,5-Diazabicyclo[2.2.1]heptane dihydrochloride

Suppliers and Price of (1S,4S)-2,5-Diazabicyclo[2.2.1]heptane dihydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

J&W Pharmlab
(1S,4S)-2,5-Diaza-bicyclo[2.2.1]heptanedihydrochloride 97%
1g
$ 155.00

J&W Pharmlab
(1S,4S)-2,5-Diaza-bicyclo[2.2.1]heptanedihydrochloride 97%
500mg
$ 115.00

J&W Pharmlab
(1S,4S)-2,5-Diaza-bicyclo[2.2.1]heptanedihydrochloride 97%
250mg
$ 98.00

J&W Pharmlab
(1S,4S)-2,5-Diaza-bicyclo[2.2.1]heptanedihydrochloride 97%
100mg
$ 85.00

J&W Pharmlab
(1S,4S)-2,5-Diaza-bicyclo[2.2.1]heptanedihydrochloride 97%
5g
$ 629.00

American Custom Chemicals Corporation
2,5-DIAZABICYCLO[2.2.1]HEPTANE DIHYDROCHLORIDE 95.00%
5MG
$ 501.27

AK Scientific
2,5-Diazabicyclo[2.2.1]heptane,dihydrochloride
10g
$ 2074.00

AK Scientific
2,5-Diazabicyclo[2.2.1]heptane,dihydrochloride
500mg
$ 377.00

AK Scientific
2,5-Diazabicyclo[2.2.1]heptane,dihydrochloride
100mg
$ 362.00

ACHEMBLOCK
(1S,4S)-2,5-diazabicyclo[2.2.1]heptanedihydrochloride 97%
5G
$ 555.00

Total 9 raw suppliers

Chemical Property of (1S,4S)-2,5-Diazabicyclo[2.2.1]heptane dihydrochloride

Chemical Property:

PSA：24.06000
LogP:1.58170
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:0
Exact Mass:170.0377538
Heavy Atom Count:9
Complexity:72.1

Purity/Quality:

99%, ^*data from raw suppliers

(1S,4S)-2,5-Diaza-bicyclo[2.2.1]heptanedihydrochloride 97% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1C2CNC1CN2.Cl.Cl
Isomeric SMILES:C1[C@H]2CN[C@@H]1CN2.Cl.Cl

Technology Process of (1S,4S)-2,5-Diazabicyclo[2.2.1]heptane dihydrochloride

There total 9 articles about (1S,4S)-2,5-Diazabicyclo[2.2.1]heptane dihydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 113451-59-5,174823-32-6
(1S,4S)-2,5-Diaza-bicyclo[2.2.1]heptane-2-carboxylic acid tert-butyl ester

: 5260-20-8,89487-38-7
(1S,4S)-2,5-Diazabicyclo<2.2.1>heptane dihydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; methanol; at 20 ℃; for 0.5h;
DOI:10.1016/j.tetlet.2013.07.092

Reference yield: 100.0%

: 132666-68-3
(1S,4S)-5-Benzyl-2-tert-butoxycarbonyl-2,5-diazabicyclo<2.2.1>heptane

: 5260-20-8,89487-38-7
(1S,4S)-2,5-Diazabicyclo<2.2.1>heptane dihydrochloride

Guidance literature:: With hydrogenchloride; hydrogen; palladium on activated charcoal; In methanol; for 3h; under 4137.2 Torr; Ambient temperature;
DOI:10.1055/s-1990-27056

Reference yield:

: 40216-83-9
L-4-hydroxyproline methyl ester hydrochloride

: 5260-20-8,89487-38-7
(1S,4S)-2,5-Diazabicyclo<2.2.1>heptane dihydrochloride

Guidance literature:: Multi-step reaction with 7 steps

1.1: triethylamine / dichloromethane / 17 h / 0 °C

2.1: lithium borohydride / tetrahydrofuran / 26 h / 0 - 20 °C

3.1: pyridine / dichloromethane / 18 h / 40 °C

4.1: trimethylsilylazide; tetrabutyl ammonium fluoride / tetrahydrofuran / 18 h / 70 °C

5.1: triethylamine / dichloromethane / 0.5 h / 0 °C

6.1: triphenylphosphine / tetrahydrofuran / 2 h / 20 °C

6.2: 18 h

7.1: hydrogenchloride / methanol; 1,4-dioxane / 0.5 h / 20 °C

With pyridine; hydrogenchloride; lithium borohydride; trimethylsilylazide; tetrabutyl ammonium fluoride; triethylamine; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; 6.1: |Staudinger Azide Reduction;
DOI:10.1016/j.tetlet.2013.07.092