C-(2-CHLORO-PHENYL)-C-PHENYL-METHYLAMINE HYDROCHLORIDE

Base Information

• Chemical Name: C-(2-CHLORO-PHENYL)-C-PHENYL-METHYLAMINE HYDROCHLORIDE
• CAS No.: 5267-36-7
• Molecular Formula: C₁₃H₁₂ClN*ClH
• Molecular Weight: 254.159
• Mol file: 5267-36-7.mol

Synonyms:C-(2-CHLORO-PHENYL)-C-PHENYL-METHYLAMINE HYDROCHLORIDE

Chemical Property of C-(2-CHLORO-PHENYL)-C-PHENYL-METHYLAMINE HYDROCHLORIDE

Chemical Property:

• PSA: 26.02000
• LogP: 4.89040

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: o-Chloro-α-phenylbenzylamine Hydrochloride is a reagent in the preparation of novel diarylalkyl carbamates on histamine H3 receptors.

Technology Process of C-(2-CHLORO-PHENYL)-C-PHENYL-METHYLAMINE HYDROCHLORIDE

There total 4 articles about C-(2-CHLORO-PHENYL)-C-PHENYL-METHYLAMINE HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 29.0%

(2-chlorophenyl)phenylmethanone oxime (71225-69-9) → (RS)-(2-chlorophenyl)phenylmethylamine hydrochloride (5267-36-7)

Guidance literature:

With sodium tetrahydroborate; titanium tetrachloride; In 1,2-dimethoxyethane; at 20 ℃; for 24h;

DOI:10.1016/S0968-0896(00)00050-X

Reference yield:

(2-chlorophenyl)(phenyl)methaniminium chloride (39272-02-1) → (+)-(2-chlorophenyl)(phenyl)methanaminium chloride (5267-36-7) + (2-chlorophenyl)(phenyl)methanaminium chloride (5267-36-7)

Guidance literature:

With (S_a)-N-benzyl-N-methyldinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepin-4-amine; bis(1,5-cyclooctadiene)diiridium(I) dichloride; hydrogen; In methanol; dichloromethane; at 20 ℃; for 36h; under 77574.3 Torr; optical yield given as %ee; enantioselective reaction; Autoclave;

DOI:10.1021/ja909583s

Reference yield:

(2-chlorophenyl)(phenyl)methaniminium chloride (39272-02-1) → (+)-(2-chlorophenyl)(phenyl)methanaminium chloride (5267-36-7) + (2-chlorophenyl)(phenyl)methanaminium chloride (5267-36-7)

Guidance literature:

With (S_a)-N-benzyl-N-methyldinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepin-4-amine; bis(1,5-cyclooctadiene)diiridium(I) dichloride; hydrogen; In methanol; dichloromethane; at 20 ℃; for 36h; under 77574.3 Torr; optical yield given as %ee; enantioselective reaction; Autoclave;

DOI:10.1021/ja909583s

upstream raw materials:

(2-chlorophenyl)phenylmethanone oxime

(2-chlorophenyl)(phenyl)methanone

(2-chlorophenyl)(phenyl)methaniminium chloride