l-Oxazepam

Base Information

• Chemical Name: l-Oxazepam
• CAS No.: 52432-54-9
• Molecular Formula: C₁₅H₁₁ClN₂O₂
• Molecular Weight: 286.718
• Mol file: 52432-54-9.mol

Synonyms:(R)-Oxazepam;2H-1,4-Benzodiazepin-2-one, 7-chloro-1,3-dihydro-3-hydroxy-5-phenyl-, (3R)- (9CI);2H-1,4-Benzodiazepin-2-one, 7-chloro-1,3-dihydro-3-hydroxy-5-phenyl-, (R)-;l-Oxazepam

Chemical Property of l-Oxazepam

Chemical Property:

• PSA: 61.69000
• LogP: 2.02150

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of l-Oxazepam

There total 10 articles about l-Oxazepam which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

d-oxazepam acetate (1824-74-4,68374-72-1,68399-22-4,68399-23-5) → (+)-Oxazepam (604-75-1,35295-88-6,40762-00-3,52432-54-9)

Guidance literature:

With sodium hydroxide; at 0 ℃; for 0.5h; Title compound not separated from byproducts;

DOI:10.1248/cpb.36.1834

Reference yield:

oxazepam (604-75-1) → (+)-Oxazepam (604-75-1,35295-88-6,40762-00-3,52432-54-9)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine

2: aq. NaOH / 0.5 h / 0 °C

With pyridine; sodium hydroxide;

DOI:10.1248/cpb.36.1834

Reference yield:

(-)-Oxazepam (604-75-1,35295-88-6,40762-00-3,52432-54-9) → (+)-Oxazepam (604-75-1,35295-88-6,40762-00-3,52432-54-9)

Guidance literature:

In water; isopropyl alcohol; at 0 ℃; Kinetics; Reaction rate. Different temperature, pH, concentration;

DOI:10.1248/cpb.36.1834

upstream raw materials:

d-oxazepam acetate

l-oxazepam acetate

(-)-Oxazepam

d-oxazepam acetate

Downstream raw materials:

(-)-Oxazepam

(+)-Oxazepam