2-[(4-Chlorobenzyl)oxy]benzaldehyde

Base Information

• Chemical Name: 2-[(4-Chlorobenzyl)oxy]benzaldehyde
• CAS No.: 52803-59-5
• Molecular Formula: C14H11ClO2
• Molecular Weight: 246.693
• Hs Code.: 2913000090
• European Community (EC) Number: 823-510-2
• DSSTox Substance ID: DTXSID10351212
• Wikidata: Q82127432
• Mol file: 52803-59-5.mol

Synonyms:2-[(4-chlorobenzyl)oxy]benzaldehyde;52803-59-5;2-[(4-chlorophenyl)methoxy]benzaldehyde;2-((4-Chlorobenzyl)oxy)benzaldehyde;2-(4-chlorobenzyloxy)benzaldehyde;MFCD00442936;SCHEMBL8371569;DTXSID10351212;AKOPNWAGXMASTH-UHFFFAOYSA-N;BBL015589;STK200380;AKOS000248913;VS-04976;BB 0217665;CS-0116517;EN300-92311;2-((4-chlorobenzyl)oxy)benzaldehyde, AldrichCPR;Z26335722

Chemical Property of 2-[(4-Chlorobenzyl)oxy]benzaldehyde

Chemical Property:

• Vapor Pressure: 3.34E-06mmHg at 25°C
• Refractive Index: 1.615
• Boiling Point: 387.3°C at 760 mmHg
• Flash Point: 161.2°C
• PSA: 26.30000
• Density: 1.247g/cm³
• LogP: 3.73150
• XLogP3: 3.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• Exact Mass: 246.0447573
• Heavy Atom Count: 17
• Complexity: 236

Purity/Quality:

97% ^*data from raw suppliers

2-[(4-Chlorobenzyl)oxy]benzaldehyde ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 43
• Safety Statements: 36/37

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C(=C1)C=O)OCC2=CC=C(C=C2)Cl

Technology Process of 2-[(4-Chlorobenzyl)oxy]benzaldehyde

There total 5 articles about 2-[(4-Chlorobenzyl)oxy]benzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

salicylaldehyde (90-02-8) + 1-Chloro-4-(chloromethyl)benzene (104-83-6) → 2-((4-chlorobenzyl)oxy)benzaldehyde (52803-59-5)

Guidance literature:

With potassium carbonate; potassium iodide; In ethanol; at 85 ℃;

DOI:10.1016/j.bmcl.2019.126623

Reference yield: 85.0%

2-methyl-benzyl alcohol (89-95-2) + 1-Chloro-4-(chloromethyl)benzene (104-83-6) → 2-((4-chlorobenzyl)oxy)benzaldehyde (52803-59-5)

Guidance literature:

With potassium carbonate; potassium iodide; In tetrahydrofuran; for 6h; Heating;

DOI:10.1016/j.bmc.2004.12.026

Reference yield: 62.0%

salicylaldehyde (90-02-8) + 4-chlorobenzyl bromide (622-95-7) → 2-((4-chlorobenzyl)oxy)benzaldehyde (52803-59-5)

Guidance literature:

With sodium hydroxide; In ethanol; 1.) 30 min., reflux; 2.) 3 h, reflux;

DOI:10.1055/s-1995-4057

upstream raw materials:

salicylaldehyde

4-chlorobenzyl bromide

2-methyl-benzyl alcohol

1-Chloro-4-(chloromethyl)benzene

Downstream raw materials:

2-[2-(4-Chlorobenzyloxy)phenyl]-1-hydroxy-4-methyl-5-(pyridin-3-yl)imidazole

2-(4-chlorophenyl)benzofuran

C₁₇H₁₁ClN₂O

C₁₅H₁₅ClN₄O

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