(5aR-trans)-3,5-dichloro-4-oxo-N-(1,4,5a,6-tetrahydro-1,7-dioxo-3H,7H-azeto[2,1-b]furo[3,4-d][1,3]thiazin-6-yl)-4H-pyridine-1-acetamide

Base Information

• Chemical Name: (5aR-trans)-3,5-dichloro-4-oxo-N-(1,4,5a,6-tetrahydro-1,7-dioxo-3H,7H-azeto[2,1-b]furo[3,4-d][1,3]thiazin-6-yl)-4H-pyridine-1-acetamide
• CAS No.: 70150-41-3
• Molecular Formula: C15H11 Cl2 N3 O5 S
• Molecular Weight: 416.241
• Mol file: 70150-41-3.mol

Synonyms:3H,7H-Azeto[2,1-b]furo[3,4-d][1,3]thiazine,1(4H)-pyridineacetamide deriv.

Chemical Property of (5aR-trans)-3,5-dichloro-4-oxo-N-(1,4,5a,6-tetrahydro-1,7-dioxo-3H,7H-azeto[2,1-b]furo[3,4-d][1,3]thiazin-6-yl)-4H-pyridine-1-acetamide

Chemical Property:

• PSA: 123.01000
• LogP: 0.69470

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Des-5-methyl-1,3,4-thiadiazole-2-thiol lactone Cefazedone is an impurity of Cefazedone (C241500), a semi-synthetic cephalosporin antibiotic. Antibacterial.

Technology Process of (5aR-trans)-3,5-dichloro-4-oxo-N-(1,4,5a,6-tetrahydro-1,7-dioxo-3H,7H-azeto[2,1-b]furo[3,4-d][1,3]thiazin-6-yl)-4H-pyridine-1-acetamide

There total 3 articles about (5aR-trans)-3,5-dichloro-4-oxo-N-(1,4,5a,6-tetrahydro-1,7-dioxo-3H,7H-azeto[2,1-b]furo[3,4-d][1,3]thiazin-6-yl)-4H-pyridine-1-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(6R)-3-acetoxymethyl-7t-[2-(3,5-dichloro-4-oxo-4H-pyridin-1-yl)-acetylamino]-8-oxo-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid (56187-36-1) → 2-(3,5-dichloro-4-oxo-4H-pyridin-1-yl)-N-((5aR)-1,7-dioxo-(5ar)-1,4,6,7-tetrahydro-3H,5aH-azeto[2,1-b]furo[3,4-d][1,3]thiazin-6t-yl)-acetamide (70150-41-3)

Guidance literature:

With hydrogenchloride; In acetone;

Reference yield:

2-(3,5-dichloro-4-oxopyridine-1(4H)-yl)acetic acid (56187-37-2) → 2-(3,5-dichloro-4-oxo-4H-pyridin-1-yl)-N-((5aR)-1,7-dioxo-(5ar)-1,4,6,7-tetrahydro-3H,5aH-azeto[2,1-b]furo[3,4-d][1,3]thiazin-6t-yl)-acetamide (70150-41-3)

Guidance literature:

Multi-step reaction with 2 steps

1: (i) SOCl₂, DMF, (ii) /BRN= 622638/, Et₃N, CH₂Cl₂

2: aq. HCl / acetone

With hydrogenchloride; In acetone;

Reference yield:

7-Aminocephalosporanic acid (957-68-6) → 2-(3,5-dichloro-4-oxo-4H-pyridin-1-yl)-N-((5aR)-1,7-dioxo-(5ar)-1,4,6,7-tetrahydro-3H,5aH-azeto[2,1-b]furo[3,4-d][1,3]thiazin-6t-yl)-acetamide (70150-41-3)

Guidance literature:

Multi-step reaction with 2 steps

1: (i) SOCl₂, DMF, (ii) /BRN= 622638/, Et₃N, CH₂Cl₂

2: aq. HCl / acetone

With hydrogenchloride; In acetone;

upstream raw materials:

(6R)-3-acetoxymethyl-7t-[2-(3,5-dichloro-4-oxo-4H-pyridin-1-yl)-acetylamino]-8-oxo-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid

2-(3,5-dichloro-4-oxopyridine-1(4H)-yl)acetic acid

7-Aminocephalosporanic acid