N-methyl-3-(10H-phenothiazin-10-yl)propan-1-amine

Base Information

• Chemical Name: N-methyl-3-(10H-phenothiazin-10-yl)propan-1-amine
• CAS No.: 17140-12-4
• Molecular Formula: C₁₆H₁₈N₂S*ClH
• Molecular Weight: 306.859
• Mol file: 17140-12-4.mol

Synonyms:10H-Phenothiazine-10-propanamine,N-methyl-, monohydrochloride (9CI); Phenothiazine, 10-[3-(methylamino)propyl]-,monohydrochloride (8CI); 10-(3-Methylaminopropyl)phenothiazine hydrochloride;Demethylpromazine hydrochloride

Chemical Property of N-methyl-3-(10H-phenothiazin-10-yl)propan-1-amine

Chemical Property:

• Vapor Pressure: 3.05E-07mmHg at 25°C
• Boiling Point: 419.4°C at 760 mmHg
• Flash Point: 207.4°C
• Density: 1.145g/cm³

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-methyl-3-(10H-phenothiazin-10-yl)propan-1-amine

There total 2 articles about N-methyl-3-(10H-phenothiazin-10-yl)propan-1-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

N-(1-chloroethoxycarbonyl)-N-methyl-10H-phenothiazine-10-propanamine → N-methyl-10H-phenothiazine-10-propanamine hydrochloride (17140-12-4)

Guidance literature:

In methanol; for 0.75h; Heating;

DOI:10.1002/1099-1344(200008)43:9<865::AID-JLCR370>3.0.CO;2-E

Reference yield:

promazine (58-40-2) → N-methyl-10H-phenothiazine-10-propanamine hydrochloride (17140-12-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 68 percent / 1,2-dichloro-ethane / 1 h / Heating

2: 93 percent / methanol / 0.75 h / Heating

In methanol; 1,2-dichloro-ethane; 1: Substitution / 2: Substitution;

DOI:10.1002/1099-1344(200008)43:9<865::AID-JLCR370>3.0.CO;2-E

upstream raw materials:

promazine