HEMATOPORPHYRIN IX DIMETHYL ESTER

Base Information

• Chemical Name: HEMATOPORPHYRIN IX DIMETHYL ESTER
• CAS No.: 5594-29-6
• Molecular Formula: C36H42N4O6
• Molecular Weight: 626.753
• Mol file: 5594-29-6.mol

Synonyms:HEMATOPORPHYRIN IX DIMETHYL ESTER;DIMETHYL-8,13-BIS(1-HYDROXYETHYL)-3,7,12,17-TETRAMETHYL-21H,23H-PORPHINE-2,18-DIPROPIONATE;haematoporphyrin IX dimethyl ester

Chemical Property of HEMATOPORPHYRIN IX DIMETHYL ESTER

Chemical Property:

• Boiling Point: 1072.6oC at 760 mmHg
• Flash Point: 602.5oC
• PSA: 149.36000
• Density: 1.25g/cm3
• LogP: 2.82250

Purity/Quality:

97% ^*data from raw suppliers

HematoporphyrinIXDimethylEster ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Hematoporphyrin IX Dimethyl Ester is a hematoporphyrin derivative used for research.

Technology Process of HEMATOPORPHYRIN IX DIMETHYL ESTER

There total 16 articles about HEMATOPORPHYRIN IX DIMETHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

3,3'-(7,12-diacetyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-diyl)-bis-propionic acid dimethyl ester → 3,3'-[7,12-bis-(1-hydroxy-ethyl)-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-diyl]-bis-propionic acid dimethyl ester (5594-29-6)

Guidance literature:

With sodium tetrahydroborate; In methanol; dichloromethane; at 20 ℃; for 1.33333h; Inert atmosphere;

DOI:10.1021/op100036c

Reference yield: 66.9%

diazomethane (186581-53-3,908094-01-9,334-88-3) + hematophorphyrin → hematoporphyrin-IX dimethyl ester (5594-29-6)

Guidance literature:

In methanol; diethyl ether; chloroform; at 0 ℃; for 3h;

DOI:10.1002/hlca.19960790607

Reference yield:

3-{5-Formyl-2-[5-formyl-3-(2-methoxycarbonyl-ethyl)-4-methyl-1H-pyrrol-2-ylmethyl]-4-methyl-1H-pyrrol-3-yl}-propionic acid methyl ester (4792-10-3) → 3,3'-[7,12-bis-(1-hydroxy-ethyl)-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-diyl]-bis-propionic acid dimethyl ester (5594-29-6)

Guidance literature:

Multi-step reaction with 2 steps

1: trifluorormethanesulfonic acid; acetic anhydride; acetic acid / 1 h / 20 °C / Inert atmosphere

2: sodium tetrahydroborate / methanol; dichloromethane / 1.33 h / 20 °C / Inert atmosphere

With sodium tetrahydroborate; trifluorormethanesulfonic acid; acetic anhydride; acetic acid; In methanol; dichloromethane; 1: MacDonald condensation;

DOI:10.1021/op100036c

upstream raw materials:

4,3'-diacetyl-5,5'-dibenzyloxycarbonyl-3,4'-dimethyl-2,2'-dipyrrylmethane

4,3'-diacetyl-3,4'-dimethyl-5,5'-diiodo-2,2'-dipyrrylmethane

3-acetyl-2-benzyloxycarbonyl-4-methyl-1H-pyrrole

ethyl 4-acetyl-3,5-dimethylpyrrole-2-carboxylate