6-(4-Ethylphenyl)-nicotinic acid

Base Information

• Chemical Name: 6-(4-Ethylphenyl)-nicotinic acid
• CAS No.: 521074-77-1
• Molecular Formula: C₁₃H₁₁NO₂
• Molecular Weight: 213.236
• Hs Code.: 2933399090
• Mol file: 521074-77-1.mol

Synonyms:6-(4-Ethylphenyl)-nicotinic acid

Chemical Property of 6-(4-Ethylphenyl)-nicotinic acid

Chemical Property:

• PSA: 50.19000
• LogP: 3.00920
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%Min ^*data from raw suppliers

6-(4-Methylphenyl)nicotinic acid 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-(4-Ethylphenyl)-nicotinic acid

There total 2 articles about 6-(4-Ethylphenyl)-nicotinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-Chloro-3-pyridinecarboxylic acid (5326-23-8) + 4-methylphenylboronic acid (5720-05-8) → 6-(4-methylphenyl)nicotinic acid (521074-77-1)

Guidance literature:

6-Chloro-3-pyridinecarboxylic acid; With tritylchloride-polystyrene resin; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 18h;

4-methylphenylboronic acid; With potassium phosphate; phenyl-phospha-adamantane; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; In tetrahydrofuran; water; at 20 ℃; for 15h;

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1.5h; Further stages.;

DOI:10.1016/j.tetlet.2004.05.110

Reference yield:

→ 1-[1-[[6-(4-methylphenyl)-3-pyridinyl]carbonyl]-1,2,3,4-tetrahydro-6-quinolinyl]ethanone (374813-29-3) + 6-(4-methylphenyl)nicotinic acid (521074-77-1)

Guidance literature:

upstream raw materials:

6-Chloro-3-pyridinecarboxylic acid

4-methylphenylboronic acid

Refernces

• 1、 -. "Melanin-concentrating hormone antagonist". . . Retrieved 2008/06/13.