2-Methoxy-5-phenylpyridine

Base Information

• Chemical Name: 2-Methoxy-5-phenylpyridine
• CAS No.: 53698-47-8
• Molecular Formula: C12H11NO
• Molecular Weight: 185.225
• Hs Code.: 2933399090
• Mol file: 53698-47-8.mol

Synonyms:2-Methoxy-5-phenylpyridine

Chemical Property of 2-Methoxy-5-phenylpyridine

Chemical Property:

• Boiling Point: 299.6±28.0 °C(Predicted)
• PKA: 3.02±0.10(Predicted)
• PSA: 22.12000
• Density: 1.077±0.06 g/cm3(Predicted)
• LogP: 2.75720
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

2-Methoxy-5-phenylpyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Methoxy-5-phenylpyridine

There total 24 articles about 2-Methoxy-5-phenylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-methoxy-5-bromopyridine (13472-85-0,1199266-76-6) + phenylboronic acid (98-80-6) → 2-methoxy-5-phenylpyridine (53698-47-8)

Guidance literature:

With Ph₂P(CH₂CH₂O)22CH₃; triethylamine; palladium dichloride; In water; at 100 ℃; for 1h; Inert atmosphere;

DOI:10.1002/aoc.1736

Reference yield: 99.0%

2-methoxy-5-bromopyridine (13472-85-0,1199266-76-6) + phenyl trimethylsiloxane (2996-92-1,46143-12-8) → 2-methoxy-5-phenylpyridine (53698-47-8)

Guidance literature:

With potassium fluoride; propylene glycol; chloro-[2-(9-phenyl-1,10-phenanthrolin-2-yl)phenyl]palladium; In dichloromethane; at 100 ℃; for 12h; Inert atmosphere;

DOI:10.1002/asia.201901155

Reference yield: 99.0%

bromobenzene (108-86-1,52753-63-6) + lithium 6-methoxypyridine-3-sulfinate → 2-methoxy-5-phenylpyridine (53698-47-8)

Guidance literature:

With palladium diacetate; potassium carbonate; tricyclohexylphosphine; In 1,4-dioxane; at 150 ℃;

DOI:10.1039/c7sc00675f

upstream raw materials:

2-chloro-5-phenylpyridine

sodium methylate

N-(6-methoxy-[3]pyridyl)-N-nitroso-acetamide

benzene

Downstream raw materials:

5-Phenyl-2(1H)-pyridinone

4-(6-methoxy-pyridin-3-yl)-benzenesulfonamide

2-hydroxy-5-phenylpyridine

1-hydroxy-5-phenylpyridin-2-one