2,4,5-TRIMETHOXYBENZYL CHLORIDE

Base Information

• Chemical Name: 2,4,5-TRIMETHOXYBENZYL CHLORIDE
• CAS No.: 53811-44-2
• Molecular Formula: C₁₀H₁₃ClO₃
• Molecular Weight: 216.664
• Mol file: 53811-44-2.mol

Synonyms:2,4,5-TRIMETHOXYBENZYL CHLORIDE

Chemical Property of 2,4,5-TRIMETHOXYBENZYL CHLORIDE

Chemical Property:

• Vapor Pressure: 0.002mmHg at 25°C
• Refractive Index: 1.505
• Boiling Point: 303.996°C at 760 mmHg
• Flash Point: 115.435°C
• PSA: 27.69000
• Density: 1.146g/cm³
• LogP: 2.45120

Purity/Quality:

> 95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,4,5-TRIMETHOXYBENZYL CHLORIDE

There total 4 articles about 2,4,5-TRIMETHOXYBENZYL CHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2,4,5-trimethoxyphenyl)methanol (30038-31-4) → 2,4,5-trimethoxybenzyl chloride (53811-44-2)

Guidance literature:

With thionyl chloride;

Reference yield:

asaronic acid (490-64-2) → 2,4,5-trimethoxybenzyl chloride (53811-44-2)

Guidance literature:

Multi-step reaction with 3 steps

1: SOCl₂

2: LiAlH₄ / diethyl ether

3: SOCl₂ / CHCl₃

With lithium aluminium tetrahydride; thionyl chloride; In diethyl ether; chloroform;

DOI:10.1016/S0960-894X(02)00291-3

Reference yield:

methyl 2,4,5-trimethoxybenzoate (20029-76-9) → 2,4,5-trimethoxybenzyl chloride (53811-44-2)

Guidance literature:

Multi-step reaction with 2 steps

1: LiAlH₄ / diethyl ether

2: SOCl₂ / CHCl₃

With lithium aluminium tetrahydride; thionyl chloride; In diethyl ether; chloroform;

DOI:10.1016/S0960-894X(02)00291-3

upstream raw materials:

(2,4,5-trimethoxyphenyl)methanol

asaronic acid

methyl 2,4,5-trimethoxybenzoate

asaraldehyde

Downstream raw materials:

2,4,5-trimethoxybenzeneacetonitrile

3-(4,5-dimethoxy-2-vinylphenyl)-5,7,8-trimethoxy-2-methyl-isoquinolin-1(2H)-one

3-(4,5-dimethoxy-2-vinylphenyl)-5,7-dimrthoxy-2-methyl-isoquinolin-1(2H)-one

1,2,3,4-tetrahydro-6,7-dimethoxy-1-(2,4,5-trimethoxybenzyl)isoquinoline

Refernces

• 1、 Hanaoka, Miyoji,Kobayashi, Nobuyuki,Shimada, Ken-ichi,Mukai, Chisato. "Chemical Transformation of Protoberberines. Part 10. A Novel Synthesis of Sanguilutine and Dihydrosanguilutine, fully Aromatised 2,3,7,8,10-Pentaoxygenated Benzophenanthridine Alkaloids". . p. 677 - 682. Retrieved 2007/10/02.