(2S,4S)-4-FLUORO-2-METHOXYCARBONYL-PYRROLIDINE HCL

Base Information

• Chemical Name: (2S,4S)-4-FLUORO-2-METHOXYCARBONYL-PYRROLIDINE HCL
• CAS No.: 58281-79-1
• Molecular Formula: C6H11ClFNO2
• Molecular Weight: 183.61
• Hs Code.: 2933998090
• Mol file: 58281-79-1.mol

Synonyms:(2S,4S)-4-FLUORO-2-METHOXYCARBONYL-PYRROLIDINE HCL;CIS-4-FLUORO-PYRROLIDINE-2-CARBOXYLIC ACID METHYL ESTER;(2S,4S)-4-Fluoro-2-methoxycarbonylpyrrolidinehydrochloride

Chemical Property of (2S,4S)-4-FLUORO-2-METHOXYCARBONYL-PYRROLIDINE HCL

Chemical Property:

• PSA: 38.33000
• LogP: 0.99020
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99%, ^*data from raw suppliers

(2S,4S)-Methyl4-fluoropyrrolidine-2-carboxylatehydrochloride ^*data from reagent suppliers

Safty Information:

• Statements: 43
• Safety Statements: 36/37

MSDS Files:

SDS file from LookChem

Useful:

• Uses: (2S,4S)-Methyl 4-fluoropyrrolidine-2-carboxylate hcl

Technology Process of (2S,4S)-4-FLUORO-2-METHOXYCARBONYL-PYRROLIDINE HCL

There total 2 articles about (2S,4S)-4-FLUORO-2-METHOXYCARBONYL-PYRROLIDINE HCL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-tert-butyl 2-methyl (2S,4S)-4-fluoropyrrolidine-1,2-dicarboxylate (203866-16-4) → (2S,4S)-methyl 4-fluoropyrrolidine-2-carboxylate hydrochloride (58281-79-1)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; chloroform; at 20 ℃; for 3h;

Reference yield:

1-tert-butyl 2-methyl (2S,4R)-4-hydroxy-1,2-pyrrolidinedicarboxylate (74844-91-0) → (2S,4S)-methyl 4-fluoropyrrolidine-2-carboxylate hydrochloride (58281-79-1)

Guidance literature:

Multi-step reaction with 2 steps

1: diethylamino-sulfur trifluoride / 1,2-dichloro-ethane / 17.5 h / -100 - 20 °C

2: hydrogenchloride / 1,4-dioxane / 2 h / 20 °C

With hydrogenchloride; diethylamino-sulfur trifluoride; In 1,4-dioxane; 1,2-dichloro-ethane;

Reference yield: 78.0%

4-tert-butyl-2,6-dimethylphenylsulfur trifluoride (947725-04-4) + (2S,4S)-methyl 4-fluoropyrrolidine-2-carboxylate hydrochloride (58281-79-1) → (2S,4S)-N-(4-tert-butyl-2,6-dimethylphenylsulfinyl)-4-fluoro-2-(methoxycarbonyl)pyrrolidine (1207990-94-0)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; Cooling with ice;

upstream raw materials:

1-tert-butyl 2-methyl (2S,4S)-4-fluoropyrrolidine-1,2-dicarboxylate

1-tert-butyl 2-methyl (2S,4R)-4-hydroxy-1,2-pyrrolidinedicarboxylate

Downstream raw materials:

(2S,4S)-N-(4-tert-butyl-2,6-dimethylphenylsulfinyl)-4-fluoro-2-(methoxycarbonyl)pyrrolidine

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