4-(Chloromethyl)-2-(furan-2-yl)-1,3-dioxolane

Base Information

• Chemical Name: 4-(Chloromethyl)-2-(furan-2-yl)-1,3-dioxolane
• CAS No.: 58403-04-6
• Molecular Formula: C8H9ClO3
• Molecular Weight: 188.61
• DSSTox Substance ID: DTXSID60391284
• Mol file: 58403-04-6.mol

Synonyms:4-(chloromethyl)-2-(furan-2-yl)-1,3-dioxolane;58403-04-6;1,3-Dioxolane,4-(chloromethyl)-2-(2-furanyl)-(9CI);F2158-1862;SCHEMBL11457323;DTXSID60391284;MFCD01117765;AKOS006242760;NS-01724;CS-0366453

Chemical Property of 4-(Chloromethyl)-2-(furan-2-yl)-1,3-dioxolane

Chemical Property:

• PSA: 31.60000
• LogP: 1.93240
• XLogP3: 1.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 188.0240218
• Heavy Atom Count: 12
• Complexity: 153

Purity/Quality:

99%min ^*data from raw suppliers

4-(chloromethyl)-2-(furan-2-yl)-1,3-dioxolane ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1C(OC(O1)C2=CC=CO2)CCl

Technology Process of 4-(Chloromethyl)-2-(furan-2-yl)-1,3-dioxolane

There total 3 articles about 4-(Chloromethyl)-2-(furan-2-yl)-1,3-dioxolane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

furfural (98-01-1) + epichlorohydrin (106-89-8,24969-06-0,13403-37-7) → 4-chloromethyl-2-furan-2-yl-[1,3]dioxolane (58403-04-6)

Guidance literature:

With tin(IV) chloride; In tetrachloromethane; at 40 - 45 ℃; for 0.333333h;

DOI:10.1007/BF00531500

Reference yield: 82.0%

furfural (98-01-1) + 3-monochloro-1,2-propanediol (96-24-2) → 4-chloromethyl-2-furan-2-yl-[1,3]dioxolane (58403-04-6)

Guidance literature:

With polystyrene-sulfonic acid resin-D₇₂; In toluene; for 5h; Heating;

DOI:10.1080/00397910600616628

Reference yield:

→ 4-chloromethyl-2-furan-2-yl-[1,3]dioxolane (58403-04-6)

Guidance literature:

Furfurol, α-Monochlorhydrin des Glyzerins/Benzol; Erwaermen;

upstream raw materials:

furfural

3-monochloro-1,2-propanediol

epichlorohydrin

Downstream raw materials:

2-(2-furyl)-4-methylene-1,3-dioxolane

Refernces

• 1、 Li, Yonghong,Zhang, Xiaojun,Ren, Tianrui,Zhou, Jiaju. "New catalytic methods for the preparation of acetals from alcohols and aldehydes". . p. 1679 - 1685. Retrieved 2007/10/03.