2-(4-Hydroxyphenyl)-5-octylpyrimidine

Base Information

• Chemical Name: 2-(4-Hydroxyphenyl)-5-octylpyrimidine
• CAS No.: 58415-63-7
• Molecular Formula: C18H24N2O
• Molecular Weight: 284.401
• Mol file: 58415-63-7.mol

Synonyms:2-(4-Hydroxyphenyl)-5-octylpyrimidine

Chemical Property of 2-(4-Hydroxyphenyl)-5-octylpyrimidine

Chemical Property:

• PSA: 45.75000
• LogP: 3.43960

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(4-Hydroxyphenyl)-5-octylpyrimidine

There total 4 articles about 2-(4-Hydroxyphenyl)-5-octylpyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

2-(methoxymethylene)decanal (439866-89-4) + p-amidinophenol hydrochloride (38148-63-9) → 4-(5-octylpyrimidin-2-yl)phenol (58415-63-7)

Guidance literature:

With sodium methylate; In methanol; at 20 ℃; for 14h; Inert atmosphere; Reflux;

DOI:10.1039/c2jm34595a

Reference yield:

1,1-dimethoxy decane (7779-41-1) → 4-(5-octylpyrimidin-2-yl)phenol (58415-63-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: trichlorophosphate / 40 °C / Inert atmosphere; Cooling with ice

1.2: 2 h / 40 - 60 °C / Inert atmosphere

2.1: sodium methylate / methanol / 14 h / 20 °C / Inert atmosphere; Reflux

With sodium methylate; trichlorophosphate; In methanol;

DOI:10.1039/c2jm34595a

Reference yield:

4-cyanophenol (767-00-0) → 4-(5-octylpyrimidin-2-yl)phenol (58415-63-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: hydrogenchloride / methanol / 2 h

1.2: 4 h / 20 - 60 °C

2.1: sodium methylate / methanol / 14 h / 20 °C / Inert atmosphere; Reflux

With hydrogenchloride; sodium methylate; In methanol;

DOI:10.1039/c2jm34595a

upstream raw materials:

1,1-dimethoxy decane

2-(methoxymethylene)decanal

p-amidinophenol hydrochloride

4-cyanophenol

Downstream raw materials:

(S)-2-Fluoro-octanoic acid 4-(5-octyl-pyrimidin-2-yl)-phenyl ester

(S)-2-Fluoro-decanoic acid 4-(5-octyl-pyrimidin-2-yl)-phenyl ester

2-[4-((S)-2-Fluoro-heptyloxy)-phenyl]-5-octyl-pyrimidine

2-[4-((S)-2-Fluoro-octyloxy)-phenyl]-5-octyl-pyrimidine