2,3-dimethoxy-N-(4-pyridinyl)benzamide

Base Information

• Chemical Name: 2,3-dimethoxy-N-(4-pyridinyl)benzamide
• CAS No.: 667886-02-4
• Molecular Formula: C14H14N2O3
• Molecular Weight: 258.27256
• DSSTox Substance ID: DTXSID20357280
• Nikkaji Number: J2.921.980J
• Wikidata: Q82137138
• ChEMBL ID: CHEMBL1718983
• Mol file: 667886-02-4.mol

Synonyms:2,3-dimethoxy-N-(4-pyridinyl)benzamide;667886-02-4;2,3-dimethoxy-N-pyridin-4-ylbenzamide;2,3-Dimethoxy-N-pyridin-4-yl-benzamide;MLS001206774;CHEMBL1718983;REGID_for_CID_849220;DTXSID20357280;HMS2825K07;STK182056;AKOS000645408;SMR000524073;2,3-dimethoxy-N-(pyridin-4-yl)benzamide;AO-548/41714249

Chemical Property of 2,3-dimethoxy-N-(4-pyridinyl)benzamide

Chemical Property:

• PSA: 63.68000
• LogP: 1.77300
• XLogP3: 1.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• Exact Mass: 258.10044231
• Heavy Atom Count: 19
• Complexity: 292

Purity/Quality:

2,3-DIMETHOXY-N-4-PYRIDINYL-BENZAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=CC(=C1OC)C(=O)NC2=CC=NC=C2

Technology Process of 2,3-dimethoxy-N-(4-pyridinyl)benzamide

There total 2 articles about 2,3-dimethoxy-N-(4-pyridinyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

4-aminopyridine (504-24-5) + 2,3-dimethoxybenzoic acid (1521-38-6) → C14H14N2O3 (667886-02-4)

Guidance literature:

2,3-dimethoxybenzoic acid; With dmap; triethylamine; 4-Nitrobenzenesulfonyl chloride; In N,N-dimethyl-formamide; for 0.333333h;

4-aminopyridine; at 0 - 20 ℃;

DOI:10.1021/ic1019422

Reference yield:

BrH*C14H14N2O3 (1263079-07-7) → C14H14N2O3 (667886-02-4)

Guidance literature:

With tetramethyl ammoniumhydroxide; In water; acetonitrile; at 20 ℃;

DOI:10.1021/ic1019422

Reference yield:

C14H14N2O3 (667886-02-4) → C12H10N2O3 (1263079-08-8)

Guidance literature:

C₁₄H₁₄N₂O₃; With boron tribromide; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;

With water; In dichloromethane; at 0 ℃; for 2h; Inert atmosphere;

DOI:10.1021/ic1019422

upstream raw materials:

4-aminopyridine

2,3-dimethoxybenzoic acid

BrH*C₁₄H₁₄N₂O₃

Downstream raw materials:

C₁₂H₁₀N₂O₃

Refernces