ENDO-N-BENZYL-ENDO-3-AMINOTROPANE

Base Information

• Chemical Name: ENDO-N-BENZYL-ENDO-3-AMINOTROPANE
• CAS No.: 63930-14-3
• Molecular Formula: C₁₄H₂₀N₂
• Molecular Weight: 216.326
• Mol file: 63930-14-3.mol

Synonyms:8-Azabicyclo[3.2.1]octan-3-amine,8-methyl-N-phenyl-, exo-

Chemical Property of ENDO-N-BENZYL-ENDO-3-AMINOTROPANE

Chemical Property:

• PSA: 15.27000
• LogP: 2.73460

Purity/Quality:

99% ^*data from raw suppliers

(3-EXO)-8-METHYL-N-PHENYL-8-AZABICYCLO[3.2.1]OCTAN-3-AMINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ENDO-N-BENZYL-ENDO-3-AMINOTROPANE

There total 1 articles about ENDO-N-BENZYL-ENDO-3-AMINOTROPANE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ 3β-Anilino-1αH,5αH-tropan (63930-14-3)

Guidance literature:

Tropinon, Anilin, NaOEt (neben α-Isomer 4);

Reference yield:

3β-Anilino-1αH,5αH-tropan (63930-14-3) → N,N-diethyl-4-{phenyl-[8-(3-phenyl-propyl)-8-aza-bicyclo[3.2.1]oct-3-yl]-amino}-benzamide

Guidance literature:

Multi-step reaction with 5 steps

1.1: Pd₂dba3; (tBu)3P; NaOtBu / toluene

2.1: 6 N aq. HCl

3.1: 100 percent / HATU

4.1: 1-chloroethylchloroformate / 1,2-dichloro-ethane / 2 h / Heating

4.2: MeOH / Heating

5.1: NaBH(OAc)3 / 1,2-dichloro-ethane

With hydrogenchloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tri-tert-butyl phosphine; carbonochloridic acid 1-chloro-ethyl ester; sodium tris(acetoxy)borohydride; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; sodium t-butanolate; In 1,2-dichloro-ethane; toluene; 1.1: Arylation / 2.1: Hydrolysis / 3.1: Acylation / 4.1: quaternization / 4.2: demethylation / 5.1: reductive alkylation;

DOI:10.1016/S0960-894X(00)00182-7

Reference yield:

3β-Anilino-1αH,5αH-tropan (63930-14-3) → N,N-diethyl-4-[phenyl(exo-8-methyl-8-azabicyclo[3.2.1]octan-3-yl)amino]benzamide (287729-31-1)

Guidance literature:

Multi-step reaction with 3 steps

1: Pd₂dba3; (tBu)3P; NaOtBu / toluene

2: 6 N aq. HCl

3: 100 percent / HATU

With hydrogenchloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tri-tert-butyl phosphine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; sodium t-butanolate; In toluene; 1: Arylation / 2: Hydrolysis / 3: Acylation;

DOI:10.1016/S0960-894X(00)00182-7

Downstream raw materials:

N,N-diethyl-4-[phenyl(exo-8-methyl-8-azabicyclo[3.2.1]octan-3-yl)amino]benzamide

N,N-diethyl-4-[phenyl(exo-8-azabicyclo[3.2.1]octan-3-yl)amino]benzamide

N,N-di-n-propyl-4-[phenyl(exo-8-methyl-8-azabicyclo[3.2.1]octan-3-yl)amino]benzamide

N,N-di-n-propyl-4-[phenyl(exo-8-azabicyclo[3.2.1]octan-3-yl)amino]benzamide