2,6-Difluoro-3-nitropyridine

Base Information

• Chemical Name: 2,6-Difluoro-3-nitropyridine
• CAS No.: 58602-02-1
• Molecular Formula: C5H2F2N2O2
• Molecular Weight: 160.08
• Hs Code.: 2933399990
• European Community (EC) Number: 823-378-6
• DSSTox Substance ID: DTXSID50464299
• Nikkaji Number: J392.190E
• Wikidata: Q72463577
• Mol file: 58602-02-1.mol

Synonyms:2,6-DIFLUORO-3-NITROPYRIDINE;58602-02-1;MFCD11044323;Pyridine, 2,6-difluoro-3-nitro-;SCHEMBL909014;DTXSID50464299;GFDZKTFHLUFNPC-UHFFFAOYSA-N;AMY39174;AKOS006308097;AB93183;CS-W000551;DS-17586;SY043099;FT-0762037;EN300-117530;A851491

Chemical Property of 2,6-Difluoro-3-nitropyridine

Chemical Property:

• Vapor Pressure: 0.0215mmHg at 25°C
• Melting Point: 6℃
• Refractive Index: 1.511
• Boiling Point: 218-220℃ (760 Torr)
• PKA: -10.13±0.10(Predicted)
• Flash Point: 110.4±25.9℃
• PSA: 58.71000
• Density: 1.555±0.06 g/cm3 (20 ºC 760 Torr)
• LogP: 1.79120
• Storage Temp.: Room temperature.
• XLogP3: 1.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 0
• Exact Mass: 160.00843363
• Heavy Atom Count: 11
• Complexity: 161

Purity/Quality:

97% ^*data from raw suppliers

2,6-difluoro-3-nitropyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=NC(=C1[N+](=O)[O-])F)F

Technology Process of 2,6-Difluoro-3-nitropyridine

There total 6 articles about 2,6-Difluoro-3-nitropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2,6-difluoro pyridine (1513-65-1) → 2,6-Difluoro-3-nitropyridine (58602-02-1)

Guidance literature:

With trifluoromethylsulfonic anhydride; tetramethylammonium nitrate; In dichloromethane; at 80 ℃; for 0.25h; Irradiation;

DOI:10.1021/jo026202q

Reference yield: 81.0%

2,6-dicholoro-3-nitropyridine (16013-85-7,136901-10-5) → 2,6-Difluoro-3-nitropyridine (58602-02-1)

Guidance literature:

With potassium fluoride; dimethylsulfone; In toluene; at 150 ℃; for 1h;

Reference yield: 74.0%

2,6-difluoro pyridine (1513-65-1) + sulfuric acid (7664-93-9) → 2,6-Difluoro-3-nitropyridine (58602-02-1)

Guidance literature:

With nitric acid;

upstream raw materials:

2,6-difluoro pyridine

2,6-dicholoro-3-nitropyridine

sulfuric acid

Downstream raw materials:

2,6-difluoropyridin-3-ylamine

1-Benzyl-4-[N-ethyl-N-(6-fluoro-3-(nitro)-2-pyridinyl)amino]piperidine

1-Benzyl-4-[N-methyl-N-(3-nitro-6-fluoro-2-pyridinyl)amino]piperidine