[2-(2-AMINO-PHENYL)-THIAZOL-4-YL]-METHANOL

Base Information

• Chemical Name: [2-(2-AMINO-PHENYL)-THIAZOL-4-YL]-METHANOL
• CAS No.: 658076-79-0
• Molecular Formula: C₁₀H₁₀N₂OS
• Molecular Weight: 206.268
• Mol file: 658076-79-0.mol

Synonyms:[2-(2-AMINO-PHENYL)-THIAZOL-4-YL]-METHANOL

Chemical Property of [2-(2-AMINO-PHENYL)-THIAZOL-4-YL]-METHANOL

Chemical Property:

• PSA: 87.38000
• LogP: 2.46580

Purity/Quality:

98%Min ^*data from raw suppliers

[2-(2-Amino-phenyl)-thiazol-4-yl]-methanol 96% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of [2-(2-AMINO-PHENYL)-THIAZOL-4-YL]-METHANOL

There total 2 articles about [2-(2-AMINO-PHENYL)-THIAZOL-4-YL]-METHANOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-nitrobenzothioamide (70102-35-1) → 2-(2'-aminolphenyl)-4-hydroxymethylthiazole (658076-79-0)

Guidance literature:

Multi-step reaction with 3 steps

1: ethanol / 2 h / Reflux

2: 5%-palladium/activated carbon; hydrogen / ethanol / 10 h

3: lithium aluminium tetrahydride / tetrahydrofuran / 1 h

With lithium aluminium tetrahydride; 5%-palladium/activated carbon; hydrogen; In tetrahydrofuran; ethanol;

DOI:10.1016/j.tet.2017.06.034

Reference yield:

ethyl 2-(2'-nitrophenyl)thiazolyl-4-carboxylate (121262-08-6) → 2-(2'-aminolphenyl)-4-hydroxymethylthiazole (658076-79-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 5%-palladium/activated carbon; hydrogen / ethanol / 10 h

2: lithium aluminium tetrahydride / tetrahydrofuran / 1 h

With lithium aluminium tetrahydride; 5%-palladium/activated carbon; hydrogen; In tetrahydrofuran; ethanol;

DOI:10.1016/j.tet.2017.06.034

Reference yield:

2-(2'-aminolphenyl)-4-hydroxymethylthiazole (658076-79-0) + copper(II) perchlorate → C10H10N2OS*Cu(2+)

Guidance literature:

In ethanol; at 25 ℃;

DOI:10.1016/j.tet.2017.06.034

upstream raw materials:

2-nitrobenzothioamide

ethyl 2-(2'-nitrophenyl)thiazolyl-4-carboxylate

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