4-Chloro-2-(trifluoromethyl)benzene-1-sulfonyl chloride

Base Information

• Chemical Name: 4-Chloro-2-(trifluoromethyl)benzene-1-sulfonyl chloride
• CAS No.: 54090-42-5
• Molecular Formula: C7H3Cl2F3O2S
• Molecular Weight: 279.06
• Hs Code.: 2904909090
• DSSTox Substance ID: DTXSID10395419
• Wikidata: Q82195504
• Mol file: 54090-42-5.mol

Synonyms:54090-42-5;4-Chloro-2-(trifluoromethyl)benzene-1-sulfonyl chloride;4-chloro-2-(trifluoromethyl)benzenesulfonyl Chloride;4-Chloro-2-(trifluoromethyl)phenylsulfonyl chloride;4-Chloro-2-(trifluoromethyl)benzenesulphonyl chloride;4-Chloro-2-(trifluoromethyl)benzene-1-sulfonylchloride;SCHEMBL2003288;DTXSID10395419;DQKPVVIVMURTDM-UHFFFAOYSA-N;CL9598;MFCD04638751;AKOS008967017;AS-46416;CS-0137586;EN300-07942;4-Chloro-2-trifluoromethylbenzenesulfonyl chloride;A870547;4-Chloro-2-(trifluoromethyl)-benzenesulfonyl chloride;Z56963366;4-chloro-2-(trifluoromethyl)benzenesulfonyl chloride, AldrichCPR

Chemical Property of 4-Chloro-2-(trifluoromethyl)benzene-1-sulfonyl chloride

Chemical Property:

• Vapor Pressure: 0.00932mmHg at 25°C
• Refractive Index: 1.497
• Boiling Point: 273.9°Cat760mmHg
• Flash Point: 119.5°C
• PSA: 42.52000
• Density: 1.626g/cm³
• LogP: 4.36710
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• XLogP3: 3.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 1
• Exact Mass: 277.9182904
• Heavy Atom Count: 15
• Complexity: 322

Purity/Quality:

98%min ^*data from raw suppliers

4-Chloro-2-(trifluoromethyl)benzenesulphonylchloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=C(C=C1Cl)C(F)(F)F)S(=O)(=O)Cl

Technology Process of 4-Chloro-2-(trifluoromethyl)benzene-1-sulfonyl chloride

There total 1 articles about 4-Chloro-2-(trifluoromethyl)benzene-1-sulfonyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ 2-trifluoromethyl-4-chlorobenzenesulfonyl chloride (54090-42-5)

Guidance literature:

1-Amino-2-trifluormethyl-4-chlorbenzol: 1) Diazotierung mit 30percentiger HCl, NaNO2 2) 30percentige HCl, Cu-sulfat, Na-bisulfit;

Reference yield:

2-trifluoromethyl-4-chlorobenzenesulfonyl chloride (54090-42-5) + 2-(3-(3-methoxypyridin-4-yl)phenyl)propan-2-amine hydrochloride → 4-chloro-N-(2-(3-(3-methoxypyridin-4-yl)phenyl)propan-2-yl)-2-(trifluoromethyl)benzenesulfonamide

Guidance literature:

2-trifluoromethyl-4-chlorobenzenesulfonyl chloride; 2-(3-(3-methoxypyridin-4-yl)phenyl)propan-2-amine hydrochloride; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃;

In dichloromethane; at 20 ℃; for 2h;

Reference yield:

2,4-difluoro-3-iodoaniline (1437316-91-0) + 2-trifluoromethyl-4-chlorobenzenesulfonyl chloride (54090-42-5) → 4-chloro-N-(2,4-difluoro-3-iodophenyl)-2-(trifluoromethyl)benzenesulfonamide

Guidance literature:

With pyridine; at 20 ℃;