d-Butorphanol tartrate

Base Information

• Chemical Name: d-Butorphanol tartrate
• CAS No.: 58787-00-1
• Molecular Formula: C25H35NO8
• Molecular Weight: 477.555
• Mol file: 58787-00-1.mol

Synonyms:d-Butorphanol tartrate;Morphinan-3,14-diol, 17-(cyclobutylmethyl)-, (9α,13α,14α)-, (2R,3R)-2,3-dihydroxybutanedioate (1:1) (salt);Morphinan-3,14-diol, 17-(cyclobutylmethyl)-, (9α,13α,14α)-, [R-(R*,R*)]-2,3-dihydroxybutanedioate (1:1) (salt)

Chemical Property of d-Butorphanol tartrate

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of d-Butorphanol tartrate

There total 4 articles about d-Butorphanol tartrate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.08%

D-tartaric acid (147-71-7,138508-61-9) + Butorphanol (42408-82-2) → butorphanol tartrate (54965-23-0,58787-00-1)

Guidance literature:

In methanol; at 65 ℃; for 0.5h;

Reference yield: 44.3%

D-tartaric acid (147-71-7,138508-61-9) + C21H29NO2 → butorphanol tartrate (54965-23-0,58787-00-1)

Guidance literature:

With ethanol;

Reference yield:

(S)-2-cyclobutylmethyl-1-(4-methoxybenzyl)octahydroisoquinoline-4a,8a-diol → butorphanol tartrate (54965-23-0,58787-00-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: borane-THF / 0.5 h / 25 - 30 °C

1.2: 16 h / 40 - 45 °C

1.3: 3 h / 0 - 30 °C

2.1: methanol / 0.5 h / 65 °C

With borane-THF; In methanol;

upstream raw materials:

D-tartaric acid

Butorphanol

Refernces

• 1、 -. "AN IMPROVED PROCESS FOR THE PREPARATION OF BUTORPHANOL TARTRATE". . . Retrieved 2017/11/03.