(3-BROMO-PYRIDIN-2-YL)-HYDRAZINE

Base Information

• Chemical Name: (3-BROMO-PYRIDIN-2-YL)-HYDRAZINE
• CAS No.: 54231-41-3
• Molecular Formula: C5H6BrN3
• Molecular Weight: 188.027
• Hs Code.: 2933990090
• Mol file: 54231-41-3.mol

Synonyms:(3-BROMO-PYRIDIN-2-YL)-HYDRAZINE

Chemical Property of (3-BROMO-PYRIDIN-2-YL)-HYDRAZINE

Chemical Property:

• Boiling Point: 265.9±50.0 °C(Predicted)
• PKA: 8.65±0.70(Predicted)
• PSA: 50.94000
• Density: 1.82±0.1 g/cm3(Predicted)
• LogP: 1.90300
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

Purity/Quality:

97% ^*data from raw suppliers

3-Bromo-2-hydrazinylpyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (3-BROMO-PYRIDIN-2-YL)-HYDRAZINE

There total 3 articles about (3-BROMO-PYRIDIN-2-YL)-HYDRAZINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

3-bromo-2-chloropyridine (52200-48-3) → 3-bromo-2-hydrazinylpyridine (54231-41-3)

Guidance literature:

With hydrazine; In 1,4-dioxane; at 20 ℃; for 15h; Heating / reflux;

Reference yield:

2,3-dibromopyridine (13534-89-9) → 3-bromo-2-hydrazinylpyridine (54231-41-3)

Guidance literature:

With hydrazine; In 1,4-dioxane; at 85 ℃; for 8h;

Reference yield:

→ 3-bromo-2-hydrazinylpyridine (54231-41-3)

Guidance literature:

2-Nitro-3-bromopyridin IIb, Hydrazinhydrat;

DOI:10.1007/BF00480925

upstream raw materials:

3-bromo-2-chloropyridine

2,3-dibromopyridine

Downstream raw materials:

N'-(3-bromopyridin-2-yl)-4-(3-(4-fluorophenyl)-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octane-1-carbohydrazide

N'-(3-bromopyridin-2-yl)-1-(4-chlorophenyl)cyclopropane-carbohydrazide

N'-(3-bromopyridin-2-yl)acetohydrazide

8-bromo-3-methyl-[1,2,4]triazolo[4,3-a]pyridine

Refernces

• 1、 Li, Jun,Kennedy, Lawrence J.,Walker, Steven J.,Wang, Haixia,Li, James J.,Hong, Zhenqiu,O'Connor, Stephen P.,Ye, Xiang-Yang,Chen, Stephanie,Wu, Shung,Yoon, David S.,Nayeem, Akbar,Camac, Daniel M.,Ramamurthy, Vidhyashankar,Morin, Paul E.,Sheriff, Steven,Wang, Mengmeng,Harper, Timothy W.,Golla, Rajasree,Seethala, Ramakrishna,Harrity, Thomas,Ponticiello, Randolph P.,Morgan, Nathan N.,Taylor, Joseph R.,Zebo, Rachel,Maxwell, Brad,Moulin, Frederick,Gordon, David A.,Robl, Jeffrey A.. "Discovery of Clinical Candidate BMS-823778 as an Inhibitor of Human 11β-Hydroxysteroid Dehydrogenase Type 1 (11β-HSD-1)". supporting information. p. 1170 - 1174. Retrieved 2018/11/27.
• 2、 Li, Jun,Kennedy, Lawrence J.,Wang, Haixia,Li, James J.,Walker, Steven J.,Hong, Zhenqiu,Oconnor, Stephen P.,Nayeem, Akbar,Camac, Daniel M.,Morin, Paul E.,Sheriff, Steven,Wang, Mengmeng,Harper, Timothy,Golla, Rajasree,Seethala, Ramakrishna,Harrity, Thomas,Ponticiello, Randolph P.,Morgan, Nathan N.,Taylor, Joseph R.,Zebo, Rachel,Gordon, David A.,Robl, Jeffrey A.. "Optimization of 1,2,4-triazolopyridines as inhibitors of human 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD-1)". supporting information. p. 803 - 808. Retrieved 2014/08/05.