3-HYDROXY-3-METHYL-D3-PENTANEDIOIC ACID

Base Information

• Chemical Name: 3-HYDROXY-3-METHYL-D3-PENTANEDIOIC ACID
• CAS No.: 59060-36-5
• Molecular Formula: C6H7D3O5
• Molecular Weight: 165.16
• Mol file: 59060-36-5.mol

Synonyms:3-HYDROXY-3-METHYL (D3)GLUTARIC ACID;3-HYDROXY-3-METHYL-D3-PENTANEDIOIC ACID

Chemical Property of 3-HYDROXY-3-METHYL-D3-PENTANEDIOIC ACID

Chemical Property:

• PSA: 94.83000
• LogP: -0.31320
• Storage Temp.: -20°C Freezer, Under inert atmosphere
• Solubility.: Methanol (Slightly), Water (Slightly)

Purity/Quality:

98%Min ^*data from raw suppliers

3-Hydroxy-3-methyl-d3-pentanedioicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-HYDROXY-3-METHYL-D3-PENTANEDIOIC ACID

There total 2 articles about 3-HYDROXY-3-METHYL-D3-PENTANEDIOIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-hydroxy-4-<2H3>methylhepta-1,6-diene (59060-35-4) → 3-hydroxy-3-<2H3>methylglutaric acid (59060-36-5)

Guidance literature:

With sulfuric acid; dihydrogen peroxide; oxygen; ozone; Yield given. Multistep reaction; 1) ethyl acetate, -78 deg C; 2) H₂O, 2 h, reflux;

Reference yield:

→ 3-hydroxy-3-<2H3>methylglutaric acid (59060-36-5)

Guidance literature:

1. d(3)-Methylheptadienol, O3 2. H2O2;

DOI:10.1016/0031-9422(75)80355-4

Reference yield: 76.0%

3-hydroxy-3-<2H3>methylglutaric acid (59060-36-5) → 3-hydroxy-3-pentane-1,5-dioic anhydride (115135-38-1)

Guidance literature:

With acetic anhydride; for 18h;

upstream raw materials:

4-hydroxy-4-<²H3>methylhepta-1,6-diene

Downstream raw materials:

3-hydroxy-3-pentane-1,5-dioic anhydride

RS-Mevalonolactone-6,6,6-2H3

Refernces

• 1、 Simpson, Thomas J.,Anmed, Salman A.,McIntyre, C. Rupert,Scott, Fiona E.,Sadler, Ian H.. "Biosynthesis of polyketide-terpenoid (Meroterpenoid) metabolites andibenin B and andilesin A in aspergillus variecolor". . p. 4013 - 4034. Retrieved 2007/10/03.
• 2、 Ahmed, Salman A.,Bardshiri, Esfandiar,Simpson, Thomas J.. "A Convenient Synthesis of Isotopically Labelled Anthraquinones, Chrysophanol, Islandicin, and Emodin. Incorporation of Chrysophanol into Tajixanthone in Aspergillus variecolor". . p. 883 - 884. Retrieved 2007/10/02.