Technology Process of 3-Indolizinecarboxylicacid,1,2,3,5,6,8a-hexahydro-5-oxo-,(3S,8aS)-(9CI)
There total 4 articles about 3-Indolizinecarboxylicacid,1,2,3,5,6,8a-hexahydro-5-oxo-,(3S,8aS)-(9CI) which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
lithium hydroxide;
In
tetrahydrofuran; water;
for 2h;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: trifluoroacetic acid / CH2Cl2 / 2 h / 20 °C
2: 3.39 g / EDC; 4-(dimethylamino)pyridine / CH2Cl2 / 0.75 h
3: 96 percent / Cl2(Cy3P)2Ru=CHPh / CH2Cl2 / 4 h / Heating
4: 94 percent / lithium hydroxide monohydrate / tetrahydrofuran; H2O / 2 h
With
dmap; lithium hydroxide; Grubbs catalyst first generation; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; trifluoroacetic acid;
In
tetrahydrofuran; dichloromethane; water;
3: Grubbs olefin metathesis reaction;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 3.39 g / EDC; 4-(dimethylamino)pyridine / CH2Cl2 / 0.75 h
2: 96 percent / Cl2(Cy3P)2Ru=CHPh / CH2Cl2 / 4 h / Heating
3: 94 percent / lithium hydroxide monohydrate / tetrahydrofuran; H2O / 2 h
With
dmap; lithium hydroxide; Grubbs catalyst first generation; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide;
In
tetrahydrofuran; dichloromethane; water;
2: Grubbs olefin metathesis reaction;