Chemical Property of Prinaberel
Chemical Property:
- Melting Point:250-252 oC
- Boiling Point:379.9 °C at 760 mmHg
- PKA:7.50±0.20(Predicted)
- Flash Point:183.6 °C
- PSA：66.49000
- Density:1.413g/cm3
- LogP:3.68810
- Storage Temp.:room temp
- Solubility.:DMSO: ≥25mg/mL
- XLogP3:3.6
- Hydrogen Bond Donor Count:2
- Hydrogen Bond Acceptor Count:5
- Rotatable Bond Count:2
- Exact Mass:271.06447134
- Heavy Atom Count:20
- Complexity:367
- Purity/Quality:
-
97% *data from raw suppliers
ERB 041 *data from reagent suppliers
Safty Information:
- Pictogram(s):
Xn
- Hazard Codes:Xn
- Statements:
22-36
- Safety Statements:
26
- MSDS Files:
-
SDS file from LookChem
Useful:
- Canonical SMILES:C=CC1=C2C(=CC(=C1)O)N=C(O2)C3=CC(=C(C=C3)O)F
- Recent ClinicalTrials:Study Evaluating Orally Administered ERB-041 in Subjects With Active Interstitial Cystitis
- Recent EU Clinical Trials:A DOUBLE-BLIND, RANDOMIZED, PLACEBO-CONTROLLED STUDY TO EVALUATE THE SAFETY AND EFFICACY OF 75 MG AND 150 MG DOSES OF ERB-041 ON THE REDUCTION OF SYMPTOMS ASSOCIATED WITH ENDOMETRIOSIS DURING TREATMENT AND POST TREATMENT IN REPRODUCTIVE-AGED WOMEN
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Uses
ERB 041 is a potent ERβ agonist; displays >200-fold selectivity for ERβ over ERα (IC50 values are 5 and 1216 nM for human ERβ and ERα; 3.1 and 620 nM for rat ERβ and ERα; and 3.7 and 750 nM for mouse ERβ and ERα respectively). Prinaberel is a potent ERβ agonist; displays >200-fold selectivity for ERβ over ERα (IC50 values are 5 and 1216 nM for human ERβ and ERα; 3.1 and 620 nM for rat ERβ and ERα; and 3.7 and 750 nM for mouse ERβ and ERα respectively).
