4-(3-NITRO-PHENYL)-THIAZOL-2-YLAMINE

Base Information

• Chemical Name: 4-(3-NITRO-PHENYL)-THIAZOL-2-YLAMINE
• CAS No.: 57493-24-0
• Molecular Formula: C9H7N3O2S
• Molecular Weight: 221.239
• Hs Code.: 2934100090
• Mol file: 57493-24-0.mol

Synonyms:Thiazole,2-amino-4-(m-nitrophenyl)- (6CI,7CI);2-Amino-4-(3-nitrophenyl)thiazole;2-Amino-4-(m-nitrophenyl)thiazole;[4-(3-Nitrophenyl)thiazol-2-yl]amine;

Chemical Property of 4-(3-NITRO-PHENYL)-THIAZOL-2-YLAMINE

Chemical Property:

• Vapor Pressure: 3.44E-08mmHg at 25°C
• Melting Point: 189-191 °C
• Refractive Index: 1.692
• Boiling Point: 447.2 °C at 760 mmHg
• PKA: 3.54±0.10(Predicted)
• Flash Point: 224.2 °C
• PSA: 112.97000
• Density: 1.459 g/cm³
• LogP: 3.40490
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

NLT 98% ^*data from raw suppliers

2-Amino-4-(3-nitrophenyl)thiazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Technology Process of 4-(3-NITRO-PHENYL)-THIAZOL-2-YLAMINE

There total 13 articles about 4-(3-NITRO-PHENYL)-THIAZOL-2-YLAMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

thiourea (17356-08-0) + 3'-nitro-2-bromoacetophenone (2227-64-7) → 4-(3-nitrophenyl)thiazol-2-ylamine (57493-24-0)

Guidance literature:

In water; at 20 ℃; for 2h;

DOI:10.1016/j.tet.2008.03.082

Reference yield: 85.0%

1-nitro-3-vinyl-benzene (586-39-0,51209-60-0) + thiourea (17356-08-0) → 4-(3-nitrophenyl)thiazol-2-ylamine (57493-24-0)

Guidance literature:

1-nitro-3-vinyl-benzene; With 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; In water; at 60 ℃; for 1h;

thiourea; In ethanol; for 1h; Reflux;

Reference yield: 82.0%

thiourea (17356-08-0) + 3-Nitroacetophenone (121-89-1) → 4-(3-nitrophenyl)thiazol-2-ylamine (57493-24-0)

Guidance literature:

With N,N,N’,N’-tetrabromobenzene-1,3-disulfonamide; In neat (no solvent); at 80 ℃; for 1.5h; Reagent/catalyst;

DOI:10.1002/aoc.4127

upstream raw materials:

thiourea

3'-nitro-2-bromoacetophenone

3-Nitroacetophenone

9-fluorenylmethoxycarbonyl isothiocyanate

Downstream raw materials:

4-(3-nitrophenyl)-2-thiazolesulfamoylic acid

2-chloro-N-(4-(3-nitrophenyl)thiazol-2-yl)acetamide

7-{[4-(3-Nitro-phenyl)-thiazol-2-ylamino]-phenyl-methyl}-quinolin-8-ol

1-(4-Chloro-phenyl)-3-[4-(3-nitro-phenyl)-thiazol-2-yl]-urea